Proteins/UNIPROT:O00305

CACNB4

ProteinUNIPROT:O00305

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting..

Function from UniProtKB (O00305), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

episodic ataxia type 5 has a germline basis in CACNB4DiseaseGenCC HGNC:1404|MONDO:0013464Inferred only
juvenile myoclonic epilepsy has a germline basis in CACNB4DiseaseGenCC HGNC:1404|MONDO:0009696Inferred only

Statements

25 statements

25 statements · 4 reference databases · Subject: CACNB4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CACNA1A interacts with CACNB4ProteinHetionet hetionet:interacts:773-785Inferred only
CACNB4 interacts with CBX3ProteinHetionet hetionet:interacts:11335-785Inferred only
FASLG interacts with CACNB4ProteinHetionet hetionet:interacts:356-785Inferred only
CACNB4 interacts with MAP1AProteinHetionet hetionet:interacts:4130-785Inferred only
CACNB4 interacts with MED31ProteinHetionet hetionet:interacts:51003-785Inferred only
CACNB4 interacts with PTNProteinHetionet hetionet:interacts:5764-785Inferred only
CACNB4 interacts with REM1ProteinHetionet hetionet:interacts:28954-785Inferred only
CACNB4 interacts with SYT1ProteinHetionet hetionet:interacts:6857-785Inferred only
CACNB4 interacts with TBL3ProteinHetionet hetionet:interacts:10607-785Inferred only
CACNB4 interacts with TROProteinHetionet hetionet:interacts:7216-785Inferred only
CACNB4 participates in Arrhythmogenic right ventricular cardiomyopathyPathwayWikiPathways WP2118Inferred only
CACNB4 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only

Show the remaining 13

CACNB4 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
CACNB4 participates in MAPK signalingPathwayWikiPathways WP382Inferred only
CACNB4 participates in NCAM signaling for neurite out-growthPathwayReactome R-HSA-375165Inferred only
CACNB4 participates in NCAM1 interactionsPathwayReactome R-HSA-419037Inferred only
CACNB4 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
CACNB4 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
CACNB4 participates in Presynaptic depolarization and calcium channel openingPathwayReactome R-HSA-112308Inferred only
CACNB4 participates in Transmission across Chemical SynapsesPathwayReactome R-HSA-112315Inferred only
CACNB4 regulates negative regulation of cell population proliferationBiological processgene ontology O00305|GO:0008285Inferred only
CACNB4 regulates negative regulation of G1/S transition of mitotic cell cycleBiological processgene ontology O00305|GO:2000134Inferred only
CACNB4 regulates positive regulation of muscle contractionBiological processgene ontology O00305|GO:0045933Inferred only
CACNB4 regulates positive regulation of protein localization to nucleolusBiological processgene ontology O00305|GO:1904751Inferred only
CACNB4 regulates regulation of synaptic vesicle exocytosisBiological processgene ontology O00305|GO:2000300Inferred only

Other names

3 names

Resolves to: CACNB4

Also called: CAB4CACNLB4Calcium channel voltage-dependent subunit beta 4

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