Pathway
Defective Intrinsic Pathway for Apoptosis
Defects in the regulation of the intrinsic pathway for apoptosis are involved in diseases associated with increased cell loss, such as neurodegenerative diseases, as well as in diseases associated with impaired elimination of harmful cells, such as cancer and autoimmunity. For review, please refer to Reed 2001, Lavrik et al. 2009, and Tuzlak et al. 2016.
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So far, Reactome has annotated apoptosis defects associated with the loss of function of the CDKN2A gene product p14ARF in cancer, loss of function of TP53 in cancer, and CDK5 dysregulation in neurodegenerative diseases.
REACT:R-HSA-9734009Reactome
What the reference databases state
Statements
24 statements
24 statements · 1 reference database · Subject: Defective Intrinsic Pathway for Apoptosis · Sources: Reactome
- APP participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- BCL2L11 participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- C1QBP participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- CAPN1 participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- CAPN2 participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- CAPNS1 participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- CAPNS2 participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- CAST participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- CDC25A participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- CDC25B participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- CDC25C participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- CDK5 participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
Show the remaining 12
- CDK5R1 participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- CDKN2A participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- FASLG participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- FOXO3 participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- GOLGA2 participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- JUN participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- LMNB1 participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- PRDX1 participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- PRDX2 participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- SOD2 participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- TP53 participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only
- YWHAE participates in Defective Intrinsic Pathway for ApoptosisProteinReactome R-HSA-9734009Inferred only