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Proteins/UNIPROT:Q8TEC5
Has E3 ubiquitin-protein ligase activity. Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation. Facilitates TNF-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity..
Function from UniProtKB (Q8TEC5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
22 statements
22 statements · 2 reference databases · Subject: SH3RF2 · Sources: gene ontology, Hetionet
1 reaction
12 names
Resolves to: SH3RF2
Reaction pageLeft to rightBalance undeterminableEC 2.3.2.23, 2.3.2.27, 6.2.1.45cytosol
Human-GEM MAR09491CC BY 4.0Reference data