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Proteins/UNIPROT:Q8N1I0

DOCK4

Protein·UNIPROT:Q8N1I0

Open in the graph

Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form. Involved in regulation of adherens junction between cells. Plays a role in cell migration..

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[Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms..

Function from UniProtKB (Q8N1I0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies has a germline basis in DOCK4DiseaseGenCC HGNC:19192|MONDO:0060490Inferred only

Statements

26 statements

26 statements · 3 reference databases · Subject: DOCK4 · Sources: gene ontology, Hetionet, Reactome

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C1orf226 covaries with DOCK4ProteinHetionet hetionet:covaries:400793-9732Inferred only
DOCK4 covaries with DDR2ProteinHetionet hetionet:covaries:4921-9732Inferred only
OR1F1 covaries with DOCK4ProteinHetionet hetionet:covaries:4992-9732Inferred only
DOCK4 covaries with RGS4ProteinHetionet hetionet:covaries:5999-9732Inferred only
TMEM229A covaries with DOCK4ProteinHetionet hetionet:covaries:730130-9732Inferred only
DOCK4 covaries with TUBA3EProteinHetionet hetionet:covaries:112714-9732Inferred only
DOCK4 interacts with EIF4A3ProteinHetionet hetionet:interacts:9732-9775Inferred only
FASLG interacts with DOCK4ProteinHetionet hetionet:interacts:356-9732Inferred only
GRB2 interacts with DOCK4ProteinHetionet hetionet:interacts:2885-9732Inferred only
GRK5 interacts with DOCK4ProteinHetionet hetionet:interacts:2869-9732Inferred only
HNRNPL interacts with DOCK4ProteinHetionet hetionet:interacts:3191-9732Inferred only
MAGOH interacts with DOCK4ProteinHetionet hetionet:interacts:4116-9732Inferred only

Show the remaining 14

DOCK4 interacts with RNF115ProteinHetionet hetionet:interacts:27246-9732Inferred only
UBC interacts with DOCK4ProteinHetionet hetionet:interacts:7316-9732Inferred only
DOCK4 participates in Factors involved in megakaryocyte development and platelet productionPathwayReactome R-HSA-983231Inferred only
DOCK4 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
DOCK4 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
DOCK4 participates in RAC2 GTPase cyclePathwayReactome R-HSA-9013404Inferred only
DOCK4 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
DOCK4 participates in RHOG GTPase cyclePathwayReactome R-HSA-9013408Inferred only
DOCK4 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
DOCK4 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
DOCK4 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
DOCK4 regulates negative regulation of vascular associated smooth muscle contractionBiological processgene ontology Q8N1I0|GO:1904694Inferred only
DOCK4 regulates positive regulation of vascular associated smooth muscle cell migrationBiological processgene ontology Q8N1I0|GO:1904754Inferred only
DOCK4 regulates regulation of postsynapse assemblyBiological processgene ontology Q8N1I0|GO:0150052Inferred only

Other names

2 names

Resolves to: DOCK4

Also called: Dedicator of cytokinesis protein 4KIAA0716

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