Proteins/UNIPROT:A1X283

SH3PXD2B

ProteinUNIPROT:A1X283

Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity)..

Function from UniProtKB (A1X283), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Frank-Ter Haar syndrome has a germline basis in SH3PXD2BDiseaseGenCC HGNC:29242|MONDO:0009579Inferred only

Statements

9 statements

9 statements · 2 reference databases · Subject: SH3PXD2B · Sources: gene ontology, Hetionet

Order

SH3PXD2B covaries with SIGLEC5ProteinHetionet hetionet:covaries:285590-8778Inferred only
FASLG interacts with SH3PXD2BProteinHetionet hetionet:interacts:285590-356Inferred only
UBC interacts with SH3PXD2BProteinHetionet hetionet:interacts:285590-7316Inferred only
SH3PXD2B regulates positive regulation of adipose tissue developmentBiological processgene ontology A1X283|GO:1904179Inferred only
SH3PXD2B regulates positive regulation of fat cell differentiationBiological processgene ontology A1X283|GO:0045600Inferred only
SH3PXD2B regulates positive regulation of gene expressionBiological processgene ontology A1X283|GO:0010628Inferred only
SH3PXD2B regulates positive regulation of multicellular organism growthBiological processgene ontology A1X283|GO:0040018Inferred only
SH3PXD2B regulates positive regulation of stress fiber assemblyBiological processgene ontology A1X283|GO:0051496Inferred only
SH3PXD2B regulates regulation of brood sizeBiological processgene ontology A1X283|GO:0060378Inferred only

Other names

6 names

Resolves to: SH3PXD2B

Also called: Adapter protein HOFIFactor for adipocyte differentiation 49FAD49KIAA1295TKS4Tyrosine kinase substrate with four SH3 domains

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