SERTAD3

Antiviral interferon-stimulated protein that plays a role in innate immunity and in the suppression of viruses through different mechanisms. Plays a role in the late phase response of TLR-induced immune effector expression (By similarity). During influenza infection, interacts with PB2, PB1, and PA to disrupt the formation of the viral RdRp complex. Inhibits zika virus by interacting with the capsid protein in the nucleolus and reducing its abundance through proteasomal degradation. Strong transcriptional coactivator..

Function from UniProtKB (Q9UJW9), read 2026-09-23. CC BY 4.0.