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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P13236

CCL4

Protein·UNIPROT:P13236

Open in the graph

Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B..

Function from UniProtKB (P13236), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

44 statements

44 statements · 4 reference databases · Subject: CCL4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CCL4 covaries with ARID4AProteinHetionet hetionet:covaries:5926-6351Inferred only
ACKR2 interacts with CCL4ProteinHetionet hetionet:interacts:1238-6351Inferred only
CCL3 interacts with CCL4ProteinHetionet hetionet:interacts:6348-6351Inferred only
CCR1 interacts with CCL4ProteinHetionet hetionet:interacts:1230-6351Inferred only
CCR3 interacts with CCL4ProteinHetionet hetionet:interacts:1232-6351Inferred only
CCR5 interacts with CCL4ProteinHetionet hetionet:interacts:1234-6351Inferred only
CCR8 interacts with CCL4ProteinHetionet hetionet:interacts:1237-6351Inferred only
CTSD interacts with CCL4ProteinHetionet hetionet:interacts:1509-6351Inferred only
CXCL8 interacts with CCL4ProteinHetionet hetionet:interacts:3576-6351Inferred only
CXCR5 interacts with CCL4ProteinHetionet hetionet:interacts:6351-643Inferred only
IDE interacts with CCL4ProteinHetionet hetionet:interacts:3416-6351Inferred only
CCL4 participates in 17q12 copy number variation syndromePathwayWikiPathways WP5287Inferred only

Show the remaining 32

CCL4 participates in Chemokine receptors bind chemokinesPathwayReactome R-HSA-380108Inferred only
CCL4 participates in Chemokine signalingPathwayWikiPathways WP3929Inferred only
CCL4 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
CCL4 participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
CCL4 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
CCL4 participates in Cytosolic DNA sensing pathwayPathwayWikiPathways WP4655Inferred only
CCL4 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
CCL4 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
CCL4 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
CCL4 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CCL4 participates in Interactions of natural killer cells in pancreatic cancerPathwayWikiPathways WP5092Inferred only
CCL4 participates in Interleukin-10 signalingPathwayReactome R-HSA-6783783Inferred only
CCL4 participates in Lung fibrosisPathwayWikiPathways WP3624Inferred only
CCL4 participates in miRNA role in immune response in sepsisPathwayWikiPathways WP4329Inferred only
CCL4 participates in Network map of SARS CoV 2 signalingPathwayWikiPathways WP5115Inferred only
CCL4 participates in Overview of proinflammatory and profibrotic mediatorsPathwayWikiPathways WP5095Inferred only
CCL4 participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
CCL4 participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
CCL4 participates in Regulation of toll like receptor signalingPathwayWikiPathways WP1449Inferred only
CCL4 participates in SARS CoV 2 innate immunity evasion and cell specific immune responsePathwayWikiPathways WP5039Inferred only
CCL4 participates in Selective expression of chemokine receptors during T cell polarizationPathwayWikiPathways WP4494Inferred only
CCL4 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CCL4 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
CCL4 participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
CCL4 participates in Toll like receptor signalingPathwayWikiPathways WP75Inferred only
CCL4 participates in Uterine natural killer cells and progesterone estrogen and chorionic gonadotropinPathwayWikiPathways WP5569Inferred only
CCL4 regulates positive regulation of calcium ion transportBiological processgene ontology P13236|GO:0051928Inferred only
CCL4 regulates positive regulation of calcium-mediated signalingBiological processgene ontology P13236|GO:0050850Inferred only
CCL4 regulates positive regulation of cell migrationBiological processgene ontology P13236|GO:0030335Inferred only
CCL4 regulates positive regulation of natural killer cell chemotaxisBiological processgene ontology P13236|GO:2000503Inferred only
CCL4 decreases the expression of MRPL12ProteinHetionet hetionet:regulates:6351-6182Inferred only
CCL4 decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:6351-6192Inferred only

Other names

19 names

Resolves to: CCL4

Also called: [Cleaved into: MIP-1-beta3-69ACT-2G-26 T-lymphocyte-secreted proteinH400HC21LAG-1LAG1Lymphocyte activation gene 1 proteinMacrophage inflammatory protein 1-betaMIP-1-betaMIP-1-beta(1-69)MIP1BPAT 744Protein H400SCYA4SIS-gamma

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Small-inducible cytokine A4

T-cell activation protein 2