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Proteins/UNIPROT:Q13395
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs..
(Microbial infection) In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA..
Function from UniProtKB (Q13395), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
112 statements
112 statements · 3 reference databases · Subject: TARBP1 · Sources: Bgee, gene ontology, Hetionet
1 reaction
CHEBI:74269+S-adenosyl-L-methionineCHEBI:74445+S-adenosyl-L-homocysteine+hydron
Catalysed by TARBP1
Reaction pageLeft to rightBalanced
Rhea RHEA:20077CC BY 4.0Reference data
6 names
Resolves to: TARBP1