a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine

Three steps

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. phosphatidylcholine 2-acylhydrolase

  Catalysed by LPCAT2, LPCAT1, LPCAT4, LPCAT3 and 18 morecytosol, endoplasmic reticulumOne of 8 routes

• L-cysteineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by LPCAT2, LPCAT1, GPAT3, GPAT2 and 3 moremitochondrial matrix

• a sphingomyelinReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. ceramide:phosphatidylcholine cholinephosphotransferase

  Catalysed by LPCAT2, LPCAT1, LPCAT4, LPCAT3 and 2 morecytosol, Golgi apparatusOne of 5 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by LPCAT2, LPCAT1, GPAT3, GPAT2 and 5 moremitochondrial matrixOne of 2 routes

• glycerolReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA
  3. a 1-acylglycerol + a 1,2-diacylglycerol = a triacylglycerol + glycerol

  Catalysed by LPCAT2, LPCAT1, MOGAT2, MOGAT3 and 6 moreOne of 4 routes

• CHEBI:17927Reach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by LPCAT2, LPCAT1, GPAT3, GPAT2 and 2 moremitochondrial matrix, cytosol

• a diacylglycerolReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

  Catalysed by LPCAT2, LPCAT1, DGAT1, MOGAT2 and 22 morecytosolOne of 2 routes

• L-glutamineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by LPCAT2, LPCAT1, GLYATL1B, GLYATL1

• CHEBI:18132Reach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine
  3. sn-Glycero-3-phosphocholine cholinephosphohydrolase

  Catalysed by LPCAT2, LPCAT1, TMEM86A, TMEM86B and 1 morecytosolOne of 2 routes

• dodecanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Lauroyl-CoA hydrolase

  Catalysed by LPCAT2, LPCAT1, ACOT7, BAAT and 2 morecytosolOne of 2 routes

• phosphatidyl-L-serineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. phosphatidylserine synthase (PC-LD pool)

  Catalysed by LPCAT2, LPCAT1, LPCAT4, LPCAT3 and 1 morecytosolOne of 2 routes

• (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoA + H2O2

  Catalysed by LPCAT2, LPCAT1, ACOX1cytosol

• 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPCAT2, LPCAT1, LPGAT1cytosol

• 11-cis-retinyl esterReach from here →
  1. a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. 11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA

  Catalysed by PNPLA8, ACSL3, AWAT2

• 13-cis-retinyl esterReach from here →
  1. a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. 13-cis-retinol + a fatty acyl-CoA = 13-cis-retinyl ester + CoA

  Catalysed by PNPLA8, ACSL3, AWAT2

• 9-cis-retinyl esterReach from here →
  1. a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. 9-cis-retinol + a fatty acyl-CoA = 9-cis-retinyl ester + CoA

  Catalysed by PNPLA8, ACSL3, AWAT2

• 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by LPCAT2, LPCAT1, MOGAT2, MOGAT1cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by LPCAT2, LPCAT1, GPAT3, GPAT2 and 5 moremitochondrial matrixOne of 2 routes

• 3-oxo-(9Z)-eicosenoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. very-long-chain 3-oxoacyl-CoA synthase ((7Z)-octadecenoyl-CoA)

  Catalysed by LPCAT2, LPCAT1, ELOVL7, ELOVL1 and 5 morecytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by LPCAT2, LPCAT1, GPAT3, GPAT2 and 5 moremitochondrial matrixOne of 5 routes

• (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by LPCAT2, LPCAT1, ACADL, ACADVL and 1 morecytosolOne of 2 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by LPCAT2, LPCAT1, GPAT3, GPAT2 and 5 moremitochondrial matrixOne of 2 routes

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by LPCAT2, LPCAT1, GPAT3, GPAT2 and 5 moremitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by LPCAT2, LPCAT1, GPAT3, GPAT2 and 5 moremitochondrial matrixOne of 2 routes

• a long-chain alcohol wax esterReach from here →
  1. a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA

  Catalysed by PNPLA8, ACSL3, AWAT1, AWAT2

• docosanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Docosanoyl-CoA hydrolase

  Catalysed by LPCAT2, LPCAT1, BAAT, ACOT6cytosolOne of 4 routes

• octadecanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Stearoyl-CoA hydrolase

  Catalysed by LPCAT2, LPCAT1, ACOT7, BAAT and 3 morecytosolOne of 4 routes

• alpha-linolenic acidReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Linolenoyl-CoA hydrolase

  Catalysed by LPCAT2, LPCAT1, ACOT7, BAAT and 1 morecytosol

• CHEBI:27540Reach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by LPCAT2, LPCAT1, GPAT3, GPAT2 and 8 moremitochondrial matrix, cytosolOne of 6 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase

  Catalysed by LPCAT2, LPCAT1, BAAT, ACOT6cytosolOne of 2 routes

• hexacosan-1-olReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. hexacosanoyl-CoA + 2 NADPH + 2 H(+) = hexacosan-1-ol + 2 NADP(+) + CoA

  Catalysed by LPCAT2, LPCAT1, FAR2cytosol

• CHEBI:28701Reach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by LPCAT2, LPCAT1, GPAT3, GPAT2 and 5 moremitochondrial matrix, peroxisomeOne of 7 routes

• chlorine(.)Reach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by LPCAT2, LPCAT1, ENPP2, SLC5A7extracellular space, cytosol

• phosphocholineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+)

  Catalysed by LPCAT2, LPCAT1, LPGAT1, SMPD1One of 4 routes

• (9Z,12Z)-octadecadienoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)

  Catalysed by LPCAT2, LPCAT1, ACOT8, ACOT2 and 2 morecytosol

• tetradecanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Myristoyl-CoA hydrolase

  Catalysed by LPCAT2, LPCAT1, ACOT7, BAAT and 3 morecytosolOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Oleoyl-CoA hydrolase

  Catalysed by LPCAT2, LPCAT1, ACOT7, BAAT and 3 morecytosol

• a 1-O-alkyl-sn-glycero-3-phosphocholineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by LPCAT2, LPCAT1, LPCAT4, LPCAT3 and 6 morecytosolOne of 3 routes

• docosan-1-olReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. docosanoyl-CoA + 2 NADPH + 2 H(+) = docosan-1-ol + 2 NADP(+) + CoA

  Catalysed by LPCAT2, LPCAT1, FAR2cytosol

• hexacosanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Hexacosanoyl-CoA hydrolase

  Catalysed by LPCAT2, LPCAT1, BAAT, ACOT6cytosolOne of 2 routes

• tetracosanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Tetracosenoyl-CoA hydrolase

  Catalysed by LPCAT2, LPCAT1, BAAT, THEM4cytosolOne of 4 routes

• an N-acyl-(4R)-4-hydroxysphinganineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. sphingosine N-acyltransferase (sphinganine)
  3. dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)

  Catalysed by LPCAT2, LPCAT1, CERS1, CERS6 and 6 morecytosolOne of 3 routes

• octadecan-1-olReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. octadecanoyl-CoA + 2 NADPH + 2 H(+) = octadecan-1-ol + 2 NADP(+) + CoA

  Catalysed by LPCAT2, LPCAT1, FAR1, FAR2cytosol

• eicosanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Eicosanoyl-CoA hydrolase

  Catalysed by LPCAT2, LPCAT1, BAAT, ACOT6 and 1 morecytosolOne of 4 routes

• (9Z)-hexadecenoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Palmitoleoyl-CoA hydrolase

  Catalysed by LPCAT2, LPCAT1, ACOT7, BAAT and 3 morecytosolOne of 2 routes

• (15Z)-tetracosenoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (15Z)-tetracosenoyl-CoA hydrolase

  Catalysed by LPCAT2, LPCAT1, BAAT, ACOT6cytosol

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Arachidonyl-CoA hydrolase

  Catalysed by LPCAT2, LPCAT1, ACOT7, BAAT and 3 morecytosolOne of 2 routes

• (11Z)-eicosenoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (11Z)-eicosenoyl-CoA hydrolase

  Catalysed by LPCAT2, LPCAT1, BAAT, ACOT6 and 1 morecytosol

• an acylcholineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by LPCAT2, LPCAT1, ENPP2, BCHE

• fatty acidReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. triacylglycerol acylhydrolase

  Catalysed by LPCAT2, LPCAT1, DGAT1, MOGAT2 and 4 morecytosol, extracellular spaceOne of 31 routes