(2R)-2-phosphoglycerate

Three steps

• propionic acidReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by ENO1, ENO2, ENO3, PKM and 7 morecytosol, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by ENO1, ENO2, ENO3, PKM and 7 morecytosol, extracellular spaceOne of 2 routes

• maleateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. transport of citrate and PEP (cytosol to mitochondria)
  3. maleate(in) + citrate(out) = maleate(out) + citrate(in)

  Catalysed by ENO1, ENO2, ENO3, SLC25A1cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. L-Serine:pyruvate aminotransferase

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosolOne of 2 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. (2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O
  2. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by ENO4, ENO1, ENO2, ENO3 and 3 moremitochondrial matrix

• 3-oxopropanoateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol

• D-serineReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. D-serine = pyruvate + NH4(+)

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol

• N-acetylneuraminateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. N-acetylneuraminate synthase
  3. N-acetylneuraminate 9-phosphate + H2O = N-acetylneuraminate + phosphate

  Catalysed by ENO1, ENO2, ENO3, NANS and 1 morecytosol

• D-glucopyranose 6-phosphateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. dATP:pyruvate 2-O-phosphotransferase
  3. dATP:D-glucose 6-phosphotransferase

  Catalysed by ENO1, ENO2, ENO3, PKM and 5 morecytosol

• (R)-lactic acidReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol

• (S)-lactic acidReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by ENO1, ENO2, ENO3, PKM and 3 morecytosol, mitochondrial matrixOne of 5 routes

• 2-iminopropanoateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosolOne of 2 routes

• a 3-acylpyruvateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol

• dGMPReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. 2-Deoxyguanosine 5-Triphosphate Pyrophosphohydrolase

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol, extracellular space

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol

• L-methionineReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by ENO1, ENO2, ENO3, PKM and 3 morecytosol

• L-alanineReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol, mitochondrial matrixOne of 18 routes

• alpha-D-glucose 1,6-bisphosphateReach from here →
  1. D-phosphoglycerate 2,3-phosphomutase
  2. ATP:3-phospho-D-glycerate 1-phosphotransferase
  3. 3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase

  Catalysed by BPGM, PGAM2, PGAM1, PGAM4 and 4 morecytosolOne of 3 routes

• dCDPReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. dATP:pyruvate 2-O-phosphotransferase
  3. cytidine/uridine monophosphate kinase (dADP)

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosolOne of 4 routes

• (3S)-citramalyl-CoAReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol

• 5-amino-2-oxopentanoateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol

• D-glyceraldehyde 3-phosphateReach from here →
  1. D-phosphoglycerate 2,3-phosphomutase
  2. ATP:3-phospho-D-glycerate 1-phosphotransferase
  3. D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)

  Catalysed by BPGM, PGAM2, PGAM1, PGAM4 and 5 morecytosol

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol

• dTMPReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. pyruvate kinase (dTDP)
  3. dTTP + H2O = dTMP + diphosphate + H(+)

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol

• alpha-D-ribose 1,5-bisphosphateReach from here →
  1. D-phosphoglycerate 2,3-phosphomutase
  2. ATP:3-phospho-D-glycerate 1-phosphotransferase
  3. (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)

  Catalysed by BPGM, PGAM2, PGAM1, PGAM4 and 4 morecytosol

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol

• beta-citrylglutamateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. transport of citrate and PEP (cytosol to mitochondria)
  3. citrate + L-glutamate + ATP = beta-citrylglutamate + ADP + phosphate + H(+)

  Catalysed by ENO1, ENO2, ENO3, SLC25A1 and 1 morecytosol, mitochondrial matrix

• thiamine(1+) diphosphateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. dATP:pyruvate 2-O-phosphotransferase
  3. Antiport of thiamine-diphosphate and dATP

  Catalysed by ENO1, ENO2, ENO3, PKM and 2 morecytosol, mitochondrial matrixOne of 2 routes

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. GTP:pyruvate 2-O-phosphotransferase
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by ENO1, ENO2, ENO3, PKM and 4 morecytosol, mitochondrial matrix