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Proteins/UNIPROT:P15259

PGAM2

Protein·UNIPROT:P15259

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Catalyzes the interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate, but with a reduced activity..

Function from UniProtKB (P15259), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

glycogen storage disease due to phosphoglycerate mutase deficiency has a germline basis in PGAM2DiseaseGenCC HGNC:8889|MONDO:0009865Inferred only

Statements

6 statements

6 statements · 2 reference databases · Subject: PGAM2 · Sources: Hetionet, Human-GEM

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PGAM2 interacts with PCLAFProteinHetionet hetionet:interacts:5224-9768Inferred only
PGAM2 interacts with SUMO2ProteinHetionet hetionet:interacts:5224-6613Inferred only
PGAM2 interacts with UBCProteinHetionet hetionet:interacts:5224-7316Inferred only
(2R)-2-phosphoglycerate is a substrate of PGAM2CompoundHuman-GEM MAR04365Inferred only
(2R)-3-phospho-glyceroyl phosphate is a substrate of PGAM2CompoundHuman-GEM MAR04371Inferred only
(2R)-3-phosphoglycerate is a substrate of PGAM2CompoundHuman-GEM MAR04365Inferred only

Reactions

4 reactions

(2R)-2-phosphoglycerate(2R)-3-phosphoglycerate
Catalysed by PGAM2 or PGAM1 or BPGM or PGAM4
Reaction pageReversibleBalancedEC 5.4.2.11GO:0005829
Human-GEM MAR04365CC BY 4.0Reference data
(2R)-3-phospho-glyceroyl phosphateMAM00569c+proton
Catalysed by PGAM2 or PGAM1 or BPGM or PGAM4

Other names

5 names

Resolves to: PGAM2

Also called: BPG-dependent PGAM 2Muscle-specific phosphoglycerate mutasePGAM-MPGAMMPhosphoglycerate mutase isozyme M

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Balanced

EC 5.4.2.11, 5.4.2.4

GO:0005829

Human-GEM MAR04371CC BY 4.0Reference data

(2R)-2-phosphoglycerate(2R)-3-phosphoglycerate

Catalysed by BPGM or PGAM2 or PGAM1 or PGAM4

Reaction pageReversibleBalance undeterminable

Rhea RHEA:15901CC BY 4.0Reference data

(2R)-3-phospho-glyceroyl phosphateCHEBI:58248+hydron

Catalysed by BPGM or PGAM2 or PGAM1 or PGAM4

Reaction pageReversibleBalance undeterminable

Rhea RHEA:17765CC BY 4.0Reference data