3-hydroxy-L-kynurenine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

546 compounds within 3 steps: 5 in 1, 104 in 2, 437 in 3

Three steps

(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes
(R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. Production of 3-Hydroxyoctadecenoylcarnitinec
Catalysed by KYNU, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol
(13Z)-eicosenoyl-CoAReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)
Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes
2-aminoprop-2-enoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)
3. D-serine = 2-aminoprop-2-enoate + H2O
Catalysed by KYNU, SLC7A10, SRRinner side of the membrane, outer side of the membrane
20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
Catalysed by KYAT3, AADAT, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes
4,8-dimethylnonanoyl-CoAReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by KYNU, CRAT, CROTmitochondrial matrix, peroxisomeOne of 3 routes
tetradecanedioyl-CoAReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal
Catalysed by KYNU, ACAA1, HSD17B4, EHHADH and 1 moremitochondrial matrix, peroxisome
hexadecanedioyl-CoAReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. Production of Hexadecanedioylcarnitine
Catalysed by KYNU, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 2 routes
pristanoyl-CoAReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. fatty-acid-CoA ligase
Catalysed by KYNU, SLC27A2mitochondrial matrix, cytosolOne of 2 routes
an L-aminoacyl-L-amino acidReach from here →
1. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O
2. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)
3. an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid
Catalysed by KMO, SLC7A11, DPEP1, DPEP2inner side of the membrane, outer side of the membrane
undecanoyl-CoAReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by KYNU, ACSM4, ACSM1, ACSM2A and 3 moremitochondrial matrix, cytosolOne of 3 routes
a fatty acyl-CoAReach from here →
1. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
Catalysed by KYAT3, AADAT, GLYATL2
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by KYNU, MOCOS, PTGS1, PTGS2One of 2 routes
(9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by KYNU, MOCOS, PTGS1, PTGS2
ursodeoxycholateReach from here →
1. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and ursodeoxycholate (cytosol to extracellular)
Catalysed by KYAT3, AADAT, GSS, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 2 routes
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by KYNU, MOCOS, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by KYNU, MOCOS, PTGS2
prostaglandin G2Reach from here →
1. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and prostaglandin G2 (cytosol to extracellular)
Catalysed by KYAT3, AADAT, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes
thio-Mo-molybdopterinReach from here →
1. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O
2. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by KMO, AADAT, MOCOSOne of 3 routes
(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by KYAT3, AADAT, GSS, GPX1 and 2 more
(5Z)-tetradecenoyl-CoAReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. long-chain-fatty-acid-CoA ligase (physeteric acid)
Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes
(3E)-decenoyl-CoAReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial
Catalysed by KYNU, ACADM, ECHS1, ACAA2 and 1 moremitochondrial matrix
2-glyceryl-prostaglandin H2Reach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by KYNU, MOCOS, PTGS2
(2R,6)-dimethylheptanoyl-CoAReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)
Catalysed by KYNU, HADHA, ACAA2, HADHBmitochondrial matrix
an N(2)-acyl-L-glutamineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. transport of alanine and glutamine (cytosol to extracellular)
3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
Catalysed by KYNU, SLC3A2, SLC7A5, SLC7A10 and 2 moreextracellular space, cytosol
(7Z)-hexadecenoyl-CoAReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes
3-methylmalateReach from here →
1. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
Catalysed by KYAT3, AADAT, CLYBL
tricosanoyl-CoAReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 4 routes
(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by KYAT3, AADAT, GSS, PTGES and 5 more
Se-methylselenocysteineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. L-selenocysteine selenide-lyase (L-alanine-forming)
3. S-Adenosyl-L-methionine:thiol S-methyltransferase
Catalysed by KYNU, SCLYcytosol
(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by KYAT3, AADAT, GSS, GPX1 and 1 more
thromboxane B2Reach from here →
1. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and thromboxane B2 (cytosol to extracellular)
Catalysed by KYAT3, AADAT, GSS, SLCO1B1cytosol, extracellular spaceOne of 2 routes
an S-substituted glutathioneReach from here →
1. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)
Catalysed by KYAT3, AADAT, GSS, GSTT4 and 22 moreOne of 2 routes
prostaglandin H1Reach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
Catalysed by KYNU, MOCOS, PTGS2
(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by KYNU, MOCOS, PTGS2
(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by KYNU, MOCOS, PTGS2
(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by KYNU, MOCOS, PTGS2
17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
Catalysed by KYNU, MOCOS, PTGS2
13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
Catalysed by KYNU, MOCOS, PTGS2
(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by KYNU, MOCOS, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by KYNU, MOCOS, PTGS2
(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O
Catalysed by KYNU, MOCOS, PTGS2
13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
Catalysed by KYNU, MOCOS, PTGS2
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by KYNU, MOCOS, PTGS1, PTGS2One of 2 routes
taurochenodeoxycholateReach from here →
1. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. solute carrier organic anion transporter (GSH)
Catalysed by KYAT3, AADAT, GSS, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 3 routes
2-(1-hydroxyethyl)thiamine diphosphateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Catalysed by KYNU, AGXT2, PDHA1, PDHB and 1 moremitochondrial matrix