1-hexadecanoyl-sn-glycero-3-phosphate

Three steps

• (7Z)-tetradecenoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 8 routes

• a 2-hexadecanoyl-6-alpha-D-glucosaminy-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + hexadecanoyl-CoA = a 2-hexadecanoyl-6-alpha-D-glucosaminy-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + CoA

  Catalysed by LYPLA2, PNPLA7, PNPLA6, SLC27A2 and 11 more

• N-acetylcysteine methyl esterReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  2. S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)
  3. S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)

  Catalysed by LYPLA2, PNPLA7, PNPLA6, PPT1

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 morecytosol, mitochondrial matrixOne of 2 routes

• octadecanoateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)
  2. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  3. Fas180

  Catalysed by DHRS7B, GNPATperoxisome, cytosol

• CHEBI:27540Reach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 11 morecytosol, mitochondrial matrixOne of 6 routes

• L-glyceraldehydeReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  2. sn-glycerol 3-phosphate + H2O = glycerol + phosphate
  3. glycerol + NADP(+) = L-glyceraldehyde + NADPH + H(+)

  Catalysed by LYPLA2, PNPLA7, PNPLA6, PGP and 2 more

• elaidic acidReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 5 routes

• CHEBI:28701Reach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 morecytosol, mitochondrial matrix, peroxisomeOne of 7 routes

• (S)-dihydroorotateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  2. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by LYPLA2, PNPLA7, PNPLA6, GPD2 and 1 more

• beta-D-fructose 1,6-bisphosphateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  2. sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)
  3. beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate

  Catalysed by LYPLA2, PNPLA7, PNPLA6, GPD1 and 4 more

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerolReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate

  Catalysed by EPHX2cytosol

• fatty acidReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. aldo-keto reductase (1-acylglycerol-3P pool)
  3. alkylglycerone phosphate synthase (acylglycerone-phosphate)

  Catalysed by AKR1A1, AGPScytosol, peroxisomeOne of 9 routes

• cholesteryl hexadecanoateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA

  Catalysed by LYPLA2, PNPLA7, PNPLA6, SLC27A2 and 11 more

• taurineReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 morecytosol, mitochondrial matrixOne of 2 routes

• an N-acylsphing-4-enineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin

  Catalysed by AGPAT2, PLPP1, PLPP3, PLPP2 and 3 more

• 1,2,3-tri-(9Z-octadecenoyl)-glycerolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoate + H(+)
  3. 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O

  Catalysed by AGPAT2, GPAT3, LCLAT1, MBOAT2 and 11 more

• 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  2. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by LYPLA2, PNPLA7, PNPLA6, GPD2 and 1 more

• glycineReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 5 morecytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 morecytosol, mitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 5 morecytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 morecytosol, mitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 7 routes

• butanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 11 morecytosol, mitochondrial matrixOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 9 routes

• glutaryl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 morecytosol, mitochondrial matrixOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 12 routes

• itaconyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 11 routes

• octanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 morecytosol, mitochondrial matrixOne of 20 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoate + H(+)
  3. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate

  Catalysed by AGPAT2, GPAT3, LCLAT1, MBOAT2 and 14 more

• phytanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. phytanate-CoA ligase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 5 morecytosol, mitochondrial matrixOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 12 morecytosol, mitochondrial matrixOne of 15 routes

• a long-chain fatty acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)
  2. 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate
  3. a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)

  Catalysed by DHRS7B, AGPS

• sn-glycerol 1-phosphateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  2. sn-glycerol 3-phosphate + H2O = glycerol + phosphate
  3. sn-glycerol 1-phosphate + H2O = glycerol + phosphate

  Catalysed by LYPLA2, PNPLA7, PNPLA6, PGP

• sphing-4-enineReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 morecytosol, mitochondrial matrix, Golgi apparatusOne of 4 routes

• spermidineReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 morecytosol, mitochondrial matrixOne of 3 routes

• L-methionineReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 morecytosol, mitochondrial matrix

• sphinganine 1-phosphateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  2. hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
  3. Sphinganine-1-phosphate pamlmitaldehyde-lyase

  Catalysed by LYPLA2, PNPLA7, PNPLA6, ALDH3B1 and 3 morecytosol

• L-alanineReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 5 morecytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 morecytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 morecytosol, mitochondrial matrix

• 3-oxosphinganineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA

  Catalysed by LYPLA2, PNPLA7, PNPLA6, SLC27A2 and 13 more

• a CDP-1,2-diacyl-sn-glycerolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  2. a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)
  3. a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)

  Catalysed by LYPLA2, PNPLA7, PNPLA6, PGS1