(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

230 compounds within 3 steps: 7 in 1, 17 in 2, 206 in 3

Three steps

CHEBI:17895Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and tyrosine (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 4 routes
all-trans-retinalReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. retinol: NADP+ oxidoreductase
Catalysed by TBXAS1, PTGS2, PTGIS, RETSAT and 6 morecytosolOne of 6 routes
fumaric acidReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. transport of fumarate and thiosulfate (cytosol to mitochondria)
Catalysed by GPX1, GPX2, GPX4, TSTD1 and 1 moremitochondrial matrix, cytosolOne of 2 routes
CHEBI:18019Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and lysine (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 2 routes
thiocyanateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. thiosulfate:cyanide sulfurtranserase
Catalysed by GPX1, GPX2, GPX4, TSTD1 and 2 moremitochondrial matrixOne of 2 routes
a diacylglycerolReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol
Catalysed by TBXAS1, PTGS2, PTGIS, RETSAT and 2 more
L-glutamineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and glutamine (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 3 moreextracellular space, cytosolOne of 4 routes
arsenic triglutathioneReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)
Catalysed by GPX1, GPX2, GPX4, GSR and 1 moreOne of 3 routes
15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione
Catalysed by GPX1, GPX2, GPX4, GSR and 1 more
(5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
Catalysed by GPX1, GPX2, GPX4, GSR
(12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
Catalysed by GPX1, GPX2, GPX4, GSR
(15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O
Catalysed by GPX1, GPX2, GPX4, GSR
(17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O
Catalysed by GPX1, GPX2, GPX4, GSR
a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O
Catalysed by GPX1, GPX2, GPX4, GSR
3',5'-diiodo-L-thyronineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 more
5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. (R)-malate + A = oxaloacetate + AH2
3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
Catalysed by TBXAS1, PTGS2, PTGIS, D2HGDH and 1 more
(6R)-5,10-methylenetetrahydrofolic acidReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. formaldehyde to 5,10-methylene-THF conversion
Catalysed by TBXAS1, PTGS2, PTGIS, KDM1A and 1 morecytosol
5,6,7,8-tetrahydrofolic acidReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
3. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Catalysed by TBXAS1, PTGS2, PTGIS, MTO1 and 2 morecytosolOne of 3 routes
S-disulfanyl-L-cysteineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 more
3-iodothyronamineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 3 moreOne of 2 routes
3-iodo-L-thyronineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 3 moreOne of 2 routes
3'-iodo-L-thyronineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 3 moreOne of 2 routes
L-thyronineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 more
thyronamineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 more
3'-iodothyronamineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 3 moreOne of 2 routes
3,3'-diiodothyronamineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 3 moreOne of 2 routes
3',5'-diiodothyronamineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 more
3,3',5'-triiodothyronamineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 more
3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal
Catalysed by GPX1, GPX2, GPX4, GSR and 1 more
a quinolReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
Catalysed by GPX1, GPX2, GPX4, GSR and 1 more
folic acidReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
3. dihydrofolate:NAD+ oxidoreductase
Catalysed by TBXAS1, PTGS2, PTGIS, MTO1 and 2 morecytosolOne of 2 routes
5(S)-HETEReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Glutathione: 15-HPETE oxidoreductase
3. Glutathione: 5-HPETE oxidoreductase
Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 8 morecytosolOne of 2 routes
CHEBI:28666Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and LTD4 (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 9 morecytosol, extracellular spaceOne of 2 routes
3-disulfanyl-L-alanineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. cystine to cysteine conversion
3. L-cystine thiocysteine-lyase (deaminating
Catalysed by GPX1, GPX2, GPX4, CTHcytosol
N-acetyl-L-cysteineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. N-acetylglutamate synthase (N-acetyl-L-cysteine)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moremitochondrial matrix
L-ascorbic acidReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
Catalysed by GPX1, GPX2, GPX4, GSR and 3 more
K(+)Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes
Cys-tRNA(Cys)Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 morecytosol
chlorine(.)Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of chloride and cysteine (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 2 routes
hydrogenselenideReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 more
glycocholateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Glutathione: 15-HPETE oxidoreductase
3. solute carrier organic anion transporter (glycocholate)
Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 3 routes
cholateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Glutathione: 15-HPETE oxidoreductase
3. solute carrier organic anion transporter (cholate)
Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 3 routes
hydrogen sulfideReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-cysteine hydrogen-sulfide-lyase (deaminating
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 morecytosolOne of 5 routes
L-aspartateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. (R)-malate + A = oxaloacetate + AH2
3. L-Aspartate:2-oxoglutarate aminotransferase
Catalysed by TBXAS1, PTGS2, PTGIS, D2HGDH and 1 moremitochondrial matrixOne of 7 routes
citric acidReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. (R)-malate + A = oxaloacetate + AH2
3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
Catalysed by TBXAS1, PTGS2, PTGIS, D2HGDH and 1 moremitochondrial matrixOne of 2 routes
an alcoholReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
Catalysed by GPX1, GPX2, GPX4, GSR and 2 more
4-hydroxy-2-oxoglutaric acidReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. (R)-malate + A = oxaloacetate + AH2
3. D-aspartate:2-oxoglutarate aminotransferase
Catalysed by TBXAS1, PTGS2, PTGIS, D2HGDH and 1 moremitochondrial matrix
(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Glutathione: 15-HPETE oxidoreductase
3. transport of arachidonate and GSH (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 8 morecytosol, extracellular spaceOne of 2 routes
di-mu-sulfido-diiron(2+)Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. De novo synthesis of 2Fe2S
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 7 moremitochondrial matrix
serotoninReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and serotonin (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 2 routes