(9Z,12Z)-octadecadienoyl-CoA

Two steps

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 10 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 7 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 8 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 7 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 8 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 5 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 7 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 5 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. fatty acyl-CoA desaturase (N-C18:2CoA -> N-C18:3CoA)
  2. fatty-acyl-CoA elongation (N-C18:3CoA)

  Catalysed by FADS1, FADS2, ELOVL4, ELOVL6 and 2 morecytosolOne of 8 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 8 routes

• heptadecanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 7 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA
  2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)

  Catalysed by AGPAT2, GPAT3, LPCAT2, AGPAT1 and 3 more

• 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphateReach from here →
  1. glycerol-3-phosphate 1-O-acyltransferase (linoleoyl-CoA)
  2. 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 1 morecytosol

• nonadecanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 7 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 3 routes

• 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
  2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)

  Catalysed by LCLAT1, TAFAZZIN

• 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Beta Oxidation of Fatty Acid
  2. octanoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACADM, ACADS, LPCAT4mitochondrial matrix

• 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholineReach from here →
  1. Beta Oxidation of Fatty Acid
  2. octanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACADM, ACADS, LPCAT1mitochondrial matrix

• a 2,3-diacyl-sn-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA

  Catalysed by MOGAT2, MOGAT1cytosol

• 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerolReach from here →
  1. Beta Oxidation of Fatty Acid
  2. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by ACADM, ACADS, LCLAT1mitochondrial matrix

• 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
  1. Beta Oxidation of Fatty Acid
  2. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by ACADM, ACADS, LCLAT1mitochondrial matrix

• 1-hexadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
  1. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by LPCAT3, MBOAT2, LPCAT1, PLA2G15

• 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
  1. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by LPCAT3, MBOAT2, LPCAT1, PLA2G15One of 3 routes

• 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enineReach from here →
  1. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by LPCAT3, MBOAT2, LPCAT1, PLA2G15

• 1-O-alkyl-3-acylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

  Catalysed by MOGAT2, AWAT2cytosol

• dodecanedioyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. Activation of dodecanedioic acid

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. Production of Sebacoylcarnitine

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. Production of Suberylcarnitine

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 8 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. Production of Hexadecanedioylcarnitine

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 2 routes

• 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerolReach from here →
  1. 1-octadecanoyl-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
  2. 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate

  Catalysed by AGPAT4, LPIN1

• pristanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. fatty-acid-CoA ligase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosolOne of 2 routes

• a 1,3-diacyl-sn-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA

  Catalysed by MOGAT1cytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT2, LPCAT1cytosol

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPCAT4cytosol

• 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Beta Oxidation of Fatty Acid
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACADM, ACADS, LPCAT4mitochondrial matrix

• undecanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosolOne of 3 routes

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. (9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)
  2. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O

  Catalysed by ACOT8, ACOT2, THEM5, ACOT4 and 2 more

• (9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. (9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)
  2. (9Z,12Z)-octadecadienoate + reduced [NADPH--hemoprotein reductase] + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ACOT8, ACOT2, THEM5, ACOT4 and 1 moreOne of 2 routes

• hexadecanoateReach from here →
  1. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

  Catalysed by LPCAT3, MBOAT2, LPCAT1, PLAAT3 and 1 more