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Proteins/UNIPROT:Q9NRZ5
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity)..
Function from UniProtKB (Q9NRZ5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
37 statements
37 statements · 6 reference databases · Subject: AGPAT4 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
13 reactions
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51mitochondrial matrix
Human-GEM MAR00580CC BY 4.0Reference data
5 names
Resolves to: AGPAT4
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00588CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00589CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00590CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00591CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00592CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+an acyl-CoACHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00593CC BY 4.0Reference data
1-acyl-sn-glycerol 3-phosphate+MAM01269cCHEBI:1146900+phosphatidic acid
Catalysed by ABHD5 or AGPAT4 or MBOAT2 or AGPAT5 or AGPAT3 or AGPAT2 or MBOAT1 or LCLAT1 or AGPAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.51cytosol
Human-GEM MAR00594CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphate+an acyl-CoAa 1,2-diacyl-sn-glycero-3-phosphate+coenzyme A(4-)
Catalysed by AGPAT2 or GPAT3 or GPAT2 or LCLAT1 or MBOAT2 or LPCAT2 or LPCAT1 or ABHD5 or AGPAT1 or AGPAT4 or AGPAT3 or PNPLA3 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19709CC BY 4.0Reference data
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA+1-hexadecanoyl-sn-glycero-3-phosphate1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate+coenzyme A(4-)
Catalysed by AGPAT4
Reaction pageLeft to rightBalanced
Rhea RHEA:55300CC BY 4.0Reference data
1-octadecanoyl-sn-glycero-3-phosphate+(9Z,12Z)-octadecadienoyl-CoA1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate+coenzyme A(4-)
Catalysed by AGPAT4
Reaction pageLeft to rightBalanced
Rhea RHEA:55304CC BY 4.0Reference data
1-octadecanoyl-sn-glycero-3-phosphate+(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate+coenzyme A(4-)
Catalysed by AGPAT4
Reaction pageLeft to rightBalanced
Rhea RHEA:55308CC BY 4.0Reference data