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Reach

hexadecanoyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

588 compounds within 3 steps: 65 in 1, 93 in 2, 430 in 3

Does it reach a compound?

Two steps

N-hexadecanoyl-sphinganine-1-phosphoethanolamineReach from here →
1. sphinganine + hexadecanoyl-CoA = N-hexadecanoylsphinganine + CoA + H(+)
2. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-sphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
Catalysed by CERS6, CERS5, CERS2, SGMS2 and 1 more
N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamineReach from here →
1. (4R)-hydroxysphinganine + hexadecanoyl-CoA = N-hexadecanoyl-(4R)-hydroxysphinganine + CoA + H(+)
2. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
Catalysed by CERS6, CERS5, SGMS2, SAMD8
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
1. sn-glycerol 3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-sn-glycero-3-phosphate + CoA
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by GPAT3, GPAT4, GPAM, AGPAT4
1,2-dihexadecanoyl-sn-glycerolReach from here →
1. 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA
2. 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate
Catalysed by AGPAT2, PLPP1, PLPP3, PLPP2 and 2 moreOne of 3 routes
cholesteryl (9Z)-hexadecenoateReach from here →
1. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. (9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA
Catalysed by SCD, SCD5, SOAT1
beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enineReach from here →
1. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
2. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
Catalysed by CERS6, TLCD3B, CERS5, CERS2 and 1 more
N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
Catalysed by LPGAT1, PLAAT5
N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. 1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
Catalysed by LPCAT3, LPCAT1, PLA2G4E

Three steps

N(omega)-methyl-L-arginineReach from here →
Catalysed by GLYATL3, AGXT2
(22S)-22-hydroxycholesterolReach from here →
Catalysed by SOAT1, CEL and 1 more

Page 4 of 12

, LIPA

, CYP11A1

lysosome, mitochondrial matrix

AReach from here →

sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

Catalysed by CERS6, TLCD3B, CERS5, CERS2 and 2 moreOne of 4 routes

(5E)-tetradecenoyl-(R)-carnitineReach from here →

(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
palmitoyl-CoA:L-carnitine O-palmitoyltransferase
carnitine O-palmitoyltransferase ((9E)-tetradecenoyl-CoA)

Catalysed by CPT2, CPT1A, CPT1B, CPT1Cperoxisome, cytosolOne of 7 routes

S-octanoyl-4'-phosphopantetheineReach from here →

hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
Beta Oxidation Fatty Acid
octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by SCD, SCD5, ACADM, ACADS and 3 moremitochondrial matrix

an acyl-4'-phosphopantetheineReach from here →

hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
acyl-CoA pool formation and breakdown
an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by SCD, SCD5, NUDT19, FITM2 and 1 morecytosol

21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoateReach from here →

11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA
11-peroxy-docosahexaenoate to DHA conversion
DHA[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate[r]

Catalysed by AWAT2, CYP2E1cytosol, endoplasmic reticulumOne of 3 routes

glycoursodeoxycholateReach from here →

hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
glycine to glycoursodeoxycholate conversion

Catalysed by GLYATL3cytosolOne of 2 routes

all-trans-3,4-didehydroretinolReach from here →

all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-3,4-didehydroretinol + 2 oxidized [adrenodoxin] + 2 H2O

Catalysed by DGAT1, PNPLA4, AWAT2, MOGAT3 and 4 more

all-trans-4-hydroxyretinolReach from here →

all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-4-hydroxyretinol + 2 oxidized [adrenodoxin] + H2O

Catalysed by DGAT1, PNPLA4, AWAT2, MOGAT3 and 4 more

1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholineReach from here →

1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPCAT3, LPCAT1, PLA2G15, CYP2W1

1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholineReach from here →

1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPCAT3, LPCAT1, PLA2G15, CYP2W1

1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholineReach from here →

1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPCAT3, LPCAT1, PLA2G15, CYP2W1

1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholineReach from here →

1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by LPCAT3, LPCAT1, PLA2G15, CYP2W1

(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →

11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA
11-peroxy-docosahexaenoate to DHA conversion
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate

Catalysed by AWAT2, ALOX5, ALOX15cytosol

19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoateReach from here →

11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA
11-peroxy-docosahexaenoate to DHA conversion
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AWAT2, CYP4F8, CYP4F12cytosol

16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoateReach from here →

11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA
11-peroxy-docosahexaenoate to DHA conversion
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AWAT2, CYP4F8, CYP4F12cytosol

13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoateReach from here →

11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA
11-peroxy-docosahexaenoate to DHA conversion
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AWAT2, CYP4F8, CYP4F12cytosol

10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoateReach from here →

11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA
11-peroxy-docosahexaenoate to DHA conversion
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AWAT2, CYP4F8, CYP4F12cytosol

N-(9Z-octadecenoyl)glycineReach from here →

hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
(9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

Catalysed by GLYATL3, GLYATL2

N-(9Z-octadecenoyl)-L-phenylalanineReach from here →

1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA
1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)
L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

Catalysed by DGAT1, AWAT2, DGAT2, PNPLA2 and 1 more

N-(9Z-octadecenoyl)-L-leucineReach from here →

1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA
1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)
N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

Catalysed by DGAT1, AWAT2, DGAT2, PNPLA2 and 1 more

N-octadecanoylglycineReach from here →

hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

Catalysed by GLYATL3, GLYATL2

(19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoateReach from here →

11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA
11-peroxy-docosahexaenoate to DHA conversion
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AWAT2, CYP1A1, CYP1A2, CYP3A4 and 4 morecytosol

(19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoateReach from here →

11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA
11-peroxy-docosahexaenoate to DHA conversion
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AWAT2, CYP1A1, CYP3A4, CYP2C8 and 3 morecytosol

cholesterol sulfateReach from here →

sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
cholesterol + 3'-phosphoadenylyl sulfate = cholesterol sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by CERS6, TLCD3B, CERS5, CERS2 and 3 moreOne of 4 routes

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamineReach from here →

1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + (9Z)-octadecenoate + H(+)

Catalysed by PRDX6, LPCAT3, LPCAT1, PLA2G4E and 1 more

(11Z,14Z,17Z-eicosatrienoyl)-cholesterolReach from here →

sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by CERS6, TLCD3B, CERS5, CERS2 and 2 more

2-hydroxyoctanoyl-CoAReach from here →

hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
Beta Oxidation Fatty Acid
octanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctanoyl-CoA + succinate + CO2

Catalysed by SCD, SCD5, ACADM, ACADS and 1 moremitochondrial matrix

11-cis-retinyl tetradecanoateReach from here →

all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA

Catalysed by DGAT1, PNPLA4, AWAT2, MOGAT3 and 2 more

all-trans-retinyl tetradecanoateReach from here →

all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA

Catalysed by DGAT1, PNPLA4, AWAT2, MOGAT3 and 3 more

1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →

1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)

Catalysed by PRDX6, LPCAT3, LPCAT1, PLA2G4E and 1 more

N-dodecanoylglycineReach from here →

hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

Catalysed by GLYATL3, GLYATL2

N-decanoylglycineReach from here →

hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

Catalysed by GLYATL3, GLYATL2

N-octanoylglycineReach from here →

hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
Beta Oxidation Fatty Acid
octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

Catalysed by SCD, SCD5, ACADM, ACADS and 1 moremitochondrial matrixOne of 2 routes

N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →

hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

Catalysed by GLYATL3, GART

L-cystine-bis-glycineReach from here →

hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

Catalysed by GLYATL3, DPEP1, DPEP2

sn-glycero-3-phosphoethanolamineReach from here →

1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by PRDX6, LPCAT3, LPCAT1, PLA2G10 and 12 moreOne of 5 routes

glycyldehydrophenylalanineReach from here →

hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

Catalysed by GLYATL3, DPEP1

1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerolReach from here →

11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA
11-peroxy-docosahexaenoate to DHA conversion
1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+)

Catalysed by AWAT2, DAGLBcytosol

1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →

1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by PRDX6, LPCAT3, LPCAT1, TAFAZZIN and 1 more

an N-(fatty acyl)-glycineReach from here →

hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

Catalysed by GLYATL3, GLYATL2