Compound
21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate
An (ω-1)-hydroxy fatty acid anion that is the conjugate base of 21-HDoHE, obtained by deprotonation of the carboxy group; major species at pH 7.3.
Definition from ChEBI (CHEBI:132025), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C22H31O3
- Mass
- 343.487 g/mol
- Charge
- -1
- InChIKey
- IXAMNXQQWDOFMN-NZONWQNASA-M
- SMILES
- CC(O)/C=CC/C=CC/C=CC/C=CC/C=CC/C=CCCC(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Statements
5 statements
5 statements · 2 reference databases · Subject: 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate · Sources: Human-GEM, Rhea
- all-cis-docosa-4,7,10,13,16,19-hexaenoic acid is converted to 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoateCompoundHuman-GEM MAR20025Inferred only
- all-cis-docosa-4,7,10,13,16,19-hexaenoic acid is converted to 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoateCompoundHuman-GEM MAR20026Inferred only
- 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate is metabolised by CYP2C19ProteinRhea RHEA:50088Inferred only
- 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate is metabolised by CYP2E1ProteinRhea RHEA:50088Inferred only
- 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate is metabolised by CYP4F3ProteinRhea RHEA:50088Inferred only
Reactions
3 reactions
all-cis-docosa-4,7,10,13,16,19-hexaenoic acid+dioxygen+FMNH2CHEBI:17621+water+21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate
Catalysed by CYP2E1
Reaction pageLeft to rightBalancedEC 1.14.14.1GO:0005783
Human-GEM MAR20025CC BY 4.0Reference data
all-cis-docosa-4,7,10,13,16,19-hexaenoic acid+dioxygen+FMNH2CHEBI:17621+water+21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate
Catalysed by CYP2E1
Reaction pageLeft to rightBalancedEC 1.14.14.1GO:0005758
Human-GEM MAR20026CC BY 4.0Reference data
all-cis-docosa-4,7,10,13,16,19-hexaenoic acid+reduced [NADPH--hemoprotein reductase]+dioxygen21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP2E1 or CYP2C19 or CYP4F3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:50088CC BY 4.0Reference data
Other names
2 names
Resolves to: 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate
- Also called
- (4Z,7Z,10Z,13Z,16Z,19Z)-21-hydroxydocosahexaenoate
- Systematic name
- (4Z,7Z,10Z,13Z,16Z,19Z)-21-hydroxydocosa-4,7,10,13,16,19-hexaenoate