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1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

23 compounds within 3 steps: 2 in 1, 3 in 2, 18 in 3

Does it reach a compound?

One step

1-O-(1Z-octadecenyl)-sn-glycero-3-phosphateReach from here →
1. 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
Catalysed by GDPD3, GDPD1, GDE1
N-hexadecanoylethanolamineReach from here →
1. 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
Catalysed by GDPD3, GDPD1, GDE1

Two steps

hexadecanoic acidReach from here →
1. 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
2. H2O[c] + Hexadecenoyl Ethanolamide, C16:1-Ethanolamide (Delta 9)[c] = ethanolamine[c] + palmitate[c]
Catalysed by GDPD3, GDPD1, GDE1, NAAAcytosol
ethanolamineReach from here →
1. 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
2. H2O[c] + Hexadecenoyl Ethanolamide, C16:1-Ethanolamide (Delta 9)[c] = ethanolamine[c] + palmitate[c]
Catalysed by GDPD3, GDPD1

Three steps

(S)-carnitineReach from here →
Catalysed by GDPD3, GDPD1, GDE1, NAAAcytosol, endoplasmic reticulumOne of 2 routes
CHEBI:1146900Reach from here →
1. 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
2. H2O[c] + Hexadecenoyl Ethanolamide, C16:1-Ethanolamide (Delta 9)[c] = ethanolamine[c] + palmitate[c]

cytosol

One of 2 routes

hexadecanoateReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
N-hexadecanoylethanolamine + H2O = ethanolamine + hexadecanoate

Catalysed by GDPD3, GDPD1, GDE1, FAAH and 2 more

Catalysed by GDPD3, GDPD1, GDE1, NAAAcytosol

acetaldehydeReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
H2O[c] + Hexadecenoyl Ethanolamide, C16:1-Ethanolamide (Delta 9)[c] = ethanolamine[c] + palmitate[c]
ethanolamine ammonia-lyase (acetaldehyde-forming)

Catalysed by GDPD3, GDPD1, GDE1, NAAAcytosol

palmitoyl-CoAReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
H2O[c] + Hexadecenoyl Ethanolamide, C16:1-Ethanolamide (Delta 9)[c] = ethanolamine[c] + palmitate[c]
Palmitate:CoA ligase (AMP-forming)

Catalysed by GDPD3, GDPD1, GDE1, NAAA and 8 morecytosolOne of 3 routes

O-phosphoethanolamineReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
H2O[c] + Hexadecenoyl Ethanolamide, C16:1-Ethanolamide (Delta 9)[c] = ethanolamine[c] + palmitate[c]
ATP:ethanolamine O-phosphotransferase

Catalysed by GDPD3, GDPD1, GDE1, NAAA and 4 morecytosol

hexadecanalReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
H2O[c] + Hexadecenoyl Ethanolamide, C16:1-Ethanolamide (Delta 9)[c] = ethanolamine[c] + palmitate[c]
2 H+[c] + NADH[c] + palmitate[c] = H2O[c] + hexadecanal[c] + NAD+[c]

Catalysed by GDPD3, GDPD1, GDE1, NAAA and 3 morecytosolOne of 3 routes

all-trans-retinyl hexadecanoateReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
N-hexadecanoylethanolamine + H2O = ethanolamine + hexadecanoate
all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

Catalysed by GDPD3, GDPD1, GDE1, FAAH and 3 more

S-hexadecanoyl-N-acetylcysteamineReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
N-hexadecanoylethanolamine + H2O = ethanolamine + hexadecanoate
S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)

Catalysed by GDPD3, GDPD1, GDE1, FAAH and 4 more

S-hexadecanoyl-N-acetylcysteine methyl esterReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
N-hexadecanoylethanolamine + H2O = ethanolamine + hexadecanoate
S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)

Catalysed by GDPD3, GDPD1, GDE1, FAAH and 3 more

octadecanoateReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
H2O[c] + Hexadecenoyl Ethanolamide, C16:1-Ethanolamide (Delta 9)[c] = ethanolamine[c] + palmitate[c]
Fas180

Catalysed by GDPD3, GDPD1, GDE1, NAAAcytosol

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
H2O[c] + Hexadecenoyl Ethanolamide, C16:1-Ethanolamide (Delta 9)[c] = ethanolamine[c] + palmitate[c]
fatty acylamide amidohydrolase

Catalysed by GDPD3, GDPD1, GDE1, NAAA and 1 morecytosol

fatty acidReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
H2O[c] + Hexadecenoyl Ethanolamide, C16:1-Ethanolamide (Delta 9)[c] = ethanolamine[c] + palmitate[c]
(10Z)-heptadecenoic acid formation

Catalysed by GDPD3, GDPD1, GDE1, NAAAcytosolOne of 4 routes

16-hydroxyhexadecanoateReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
H2O[c] + Hexadecenoyl Ethanolamide, C16:1-Ethanolamide (Delta 9)[c] = ethanolamine[c] + palmitate[c]
Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum

Catalysed by GDPD3, GDPD1, GDE1, NAAA and 2 morecytosol, endoplasmic reticulumOne of 3 routes

hexadecanoyl-CoAReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
N-hexadecanoylethanolamine + H2O = ethanolamine + hexadecanoate
hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate

Catalysed by GDPD3, GDPD1, GDE1, FAAH and 13 more

phosphoethanolamineReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
H2O[c] + Hexadecenoyl Ethanolamide, C16:1-Ethanolamide (Delta 9)[c] = ethanolamine[c] + palmitate[c]
ethanolamine + ATP = phosphoethanolamine + ADP + H(+)

Catalysed by GDPD3, GDPD1, GDE1, NAAA and 4 morecytosol

N-hexadecanoylsphing-4-enineReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
N-hexadecanoylethanolamine + H2O = ethanolamine + hexadecanoate
N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate

Catalysed by GDPD3, GDPD1, GDE1, FAAH and 5 more

(R)-2-hydroxyhexadecanoateReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
N-hexadecanoylethanolamine + H2O = ethanolamine + hexadecanoate
hexadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O

Catalysed by GDPD3, GDPD1, GDE1, FAAH and 3 more

a 1-O-alkyl-sn-glycero-3-phosphoethanolamineReach from here →

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)
H2O[c] + Hexadecenoyl Ethanolamide, C16:1-Ethanolamide (Delta 9)[c] = ethanolamine[c] + palmitate[c]
a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)

Catalysed by GDPD3, GDPD1, GDE1, NAAA and 1 morecytosol