(2E)-dodecenoyl-CoA

Three steps

• 11-cis-retinyl tetradecanoateReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. 11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA

  Catalysed by MECR, AWAT2mitochondrial matrix, cytosolOne of 2 routes

• 9-cis-retinyl tetradecanoateReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. 9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA

  Catalysed by MECR, AWAT2mitochondrial matrix, cytosol

• 13-cis-retinyl tetradecanoateReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. 13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA

  Catalysed by MECR, AWAT2mitochondrial matrix, cytosol

• all-trans-retinyl tetradecanoateReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA

  Catalysed by MECR, AWAT2mitochondrial matrix, cytosol

• tetradecyl tetradecanoateReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. tetradecan-1-ol + tetradecanoyl-CoA = tetradecyl tetradecanoate + CoA

  Catalysed by MECR, AWAT2mitochondrial matrix, cytosol

• 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol

• N-hexadecanoylglycineReach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix

• N-octanoylglycineReach from here →
  1. Production of Dodecenoylcarnitine
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, CROT and 1 morecytosol, mitochondrial matrixOne of 2 routes

• N-decanoyl-(2S)-hydroxyglycineReach from here →
  1. Fatty Acid Beta Xoidation (C12:1->C10), Peroxisomal
  2. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)
  3. N-decanoylglycine + 2 L-ascorbate + O2 = N-decanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by ACAA1, HSD17B4, EHHADH, GLYATL2 and 1 moreperoxisome

• N-dodecanoyl-(2S)-hydroxyglycineReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by MECR, GLYATL2, PAMmitochondrial matrix

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix

• L-cystine-bis-glycineReach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 4 morecytosol, mitochondrial matrix

• an N-octadecanoyl-sphingoid baseReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosol

• glycyldehydrophenylalanineReach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix

• an N-(fatty acyl)-glycineReach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 2 morecytosol, mitochondrial matrix

• 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosolOne of 2 routes

• cholesteryl (7Z)-octadecenoateReach from here →
  1. Production of Dodecenoylcarnitine
  2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  3. (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SOAT1cytosol

• acetylcholineReach from here →
  1. Production of Dodecenoylcarnitine
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, CHATcytosol, nucleusOne of 3 routes

• pyruvateReach from here →
  1. Production of Dodecenoylcarnitine
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by CPT1A, CPT1C, CPT1B, AGXT2cytosol, mitochondrial matrixOne of 20 routes

• CHEBI:15467Reach from here →
  1. Production of Dodecenoylcarnitine
  2. Acetoacetate:CoA ligase (AMP-forming)
  3. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, AACS and 1 morecytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 4 morecytosol, mitochondrial matrix, extracellular spaceOne of 3 routes

• (S)-malateReach from here →
  1. Production of Dodecenoylcarnitine
  2. ATP citrate lyase (citrate)
  3. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by CPT1A, CPT1C, CPT1B, ACLYcytosol, mitochondrial matrixOne of 5 routes

• L-leucineReach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and leucine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 21 routes

• CHEBI:15611Reach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix

• CHEBI:15699Reach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 17 routes

• betaine aldehydeReach from here →
  1. Production of Dodecenoylcarnitine
  2. Acetyl-CoA:choline O-acetyltransferase
  3. choline dehydrogenase (choline)

  Catalysed by CPT1A, CPT1C, CPT1B, CHAT and 1 morecytosol, nucleusOne of 3 routes

• trimethylenediamineReach from here →
  1. Production of Dodecenoylcarnitine
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by CPT1A, CPT1C, CPT1B, SAT1 and 2 morecytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. Production of Dodecenoylcarnitine
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, endoplasmic reticulumOne of 4 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by MECR, GNPATmitochondrial matrix, cytosol

• CHEBI:15971Reach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 11 routes

• phosphatidylethanolamineReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by MECR, LPCAT4, LPCAT3, LPCAT2 and 2 moremitochondrial matrix, cytosol

• 11-cis-retinalReach from here →
  1. Production of Dodecenoylcarnitine
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol:NAD+ oxidoreductase

  Catalysed by CPT1A, CPT1C, CPT1B, DGAT1 and 11 morecytosolOne of 4 routes

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by MECR, LPCAT4, LPCAT3, LPCAT2 and 1 moremitochondrial matrix, cytosol

• hexadecan-1-olReach from here →
  1. Production of Dodecenoylcarnitine
  2. Palmitate:CoA ligase (AMP-forming)
  3. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosol, peroxisome

• 11-cis-retinyl hexadecanoateReach from here →
  1. Production of Dodecenoylcarnitine
  2. Palmitate:CoA ligase (AMP-forming)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 12 morecytosolOne of 3 routes

• L-cystineReach from here →
  1. Production of Dodecenoylcarnitine
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by CPT1A, CPT1C, CPT1B, SLC7A9 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 5 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. Production of Dodecenoylcarnitine
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by CPT1A, CPT1C, CPT1B, AGXT2cytosol, mitochondrial matrix

• phosphatidic acidReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by MECR, AGPAT2, LCLAT1, MBOAT1 and 6 moremitochondrial matrix, cytosolOne of 7 routes

• (R)-carnitineReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  3. dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA

  Catalysed by MECR, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosol

• L-citrullineReach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 5 morecytosol, mitochondrial matrix, extracellular spaceOne of 8 routes

• L-valineReach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 20 routes

• L-arginineReach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 18 routes

• CHEBI:16523Reach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 4 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. PROTEIN_BS

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 2 morecytosol, mitochondrial matrixOne of 5 routes

• CHEBI:16633Reach from here →
  1. Production of Dodecenoylcarnitine
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, SCLYcytosol, mitochondrial matrix

• Met-tRNA(Met)Reach from here →
  1. Production of Dodecenoylcarnitine
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, NAGS and 1 morecytosol, mitochondrial matrix

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. Production of Dodecenoylcarnitine
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by CPT1A, CPT1C, CPT1B, NAGS and 1 morecytosol, mitochondrial matrix

• 8-hydroxydodecanoateReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. Lauroyl-CoA hydrolase
  3. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 8-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by MECR, ACOT7, BAAT, ACOT1 and 2 moremitochondrial matrix, cytosol

• 10-hydroxydodecanoateReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. Lauroyl-CoA hydrolase
  3. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by MECR, ACOT7, BAAT, ACOT1 and 2 moremitochondrial matrix, cytosol