(2E)-dodecenoyl-CoA

Two steps

• glycineReach from here →
  1. Production of Dodecenoylcarnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 2 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by CPT1A, CPT1C, CPT1B, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, ACP2cytosol, lysosomeOne of 2 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, ACAA1 and 1 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, ACSM4 and 5 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. Production of Glutaryl Carnitine

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, SUCLG1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)

  Catalysed by MECRmitochondrial matrix, cytosolOne of 12 routes

• octanoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, CROTcytosol, mitochondrial matrixOne of 21 routes

• phytanoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. phytanate-CoA ligase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 6 morecytosolOne of 15 routes

• sphing-4-enineReach from here →
  1. Production of Dodecenoylcarnitine
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 3 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Production of Dodecenoylcarnitine
  2. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by CPT1A, CPT1C, CPT1B, SAT1 and 1 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. Production of Dodecenoylcarnitine
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by CPT1A, CPT1C, CPT1B, NAGScytosol, mitochondrial matrix

• L-alanineReach from here →
  1. Production of Dodecenoylcarnitine
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. Production of Dodecenoylcarnitine
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by CPT1A, CPT1C, CPT1B, NAGScytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. Production of Dodecenoylcarnitine
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by CPT1A, CPT1C, CPT1B, NAGScytosol, mitochondrial matrix

• an acyl-CoAReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown

  Catalysed by MECRmitochondrial matrix, cytosolOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 1 morecytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 1 morecytosolOne of 4 routes

• (2E)-decenoyl-CoAReach from here →
  1. Fatty Acid Beta Xoidation (C12:1->C10), Peroxisomal
  2. trans-dec-2-enoyl-CoA reductase

  Catalysed by ACAA1, HSD17B4, EHHADH, MECRperoxisome, mitochondrial matrixOne of 5 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. Carnitine O-Palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 11 routes

• 3-oxotetradecanoyl-CoAReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. dodecanoyl-CoA + malonyl-CoA + H(+) = 3-oxotetradecanoyl-CoA + CO2 + CoA

  Catalysed by MECR, ELOVL6mitochondrial matrix

• 3-hydroxyisovaleryl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol

• CHEBI:63544Reach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 9 routes

• 3-oxotetradecasphinganineReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. dodecanoyl-CoA + L-serine + H(+) = 3-oxotetradecasphinganine + CO2 + CoA

  Catalysed by MECR, SPTLC1, SPTLC3mitochondrial matrix

• (2E)-octadecenoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. Carnitine O-Palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 8 routes

• 1-dodecanoyl-sn-glycerol 3-phosphateReach from here →
  1. trans-dodec-2-enoyl-CoA reductase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)

  Catalysed by MECR, GPAT3, GPAT2, GPAT4 and 1 moremitochondrial matrix, cytosolOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. Production of Dodecenoylcarnitine
  2. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 6 routes