potassium atom

Three steps

• L-2-aminohexanoateReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
  3. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreextracellular space, cytosol

• 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreextracellular space, cytosolOne of 2 routes

• 5-guanidino-2-oxopentanoateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, IL4I1extracellular space, cytosol

• (3Z)-dodecenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• S-sulfanyl-L-cysteineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by SLC12A2, SLC12A1, SLC6A14, CARS2extracellular space, cytosol

• N-formyl-L-kynurenineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan + O2 = N-formyl-L-kynurenine

  Catalysed by SLC12A2, SLC12A1, SLC6A14, IDO1 and 2 moreextracellular space, cytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosol, mitochondrial matrix, endoplasmic reticulumOne of 3 routes

• 5-phospho-beta-D-ribosylamineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, PPATextracellular space, cytosolOne of 2 routes

• phosphoenolpyruvateReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosol, mitochondrial matrix

• D-glucosamine 6-phosphateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

  Catalysed by SLC12A2, SLC12A1, SLC6A14, GFPT2 and 1 moreextracellular space, cytosol

• L-methionine (S)-S-oxideReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC12A2, SLC12A1, SLC6A14, MSRAextracellular space, cytosol

• L-methionine (R)-S-oxideReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC12A2, SLC12A1, SLC6A14, MSRB3 and 2 moreextracellular space, cytosol

• deoxycholoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• S-sulfanylglutathioneReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3, SQORextracellular space, cytosol, mitochondrial matrix

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 2 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by SLC12A2, SLC12A1, SLC6A14, PPCSextracellular space, cytosolOne of 4 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-iodo-L-tyrosineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Tyrosine by Atb0 Transporter
  3. thyroid peroxidase (iodine)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, TPOextracellular space, cytosolOne of 2 routes

• dopamineReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycolithocholate 3-sulfateReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-prolineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, SLC1A4extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• estrone 3-sulfateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by SLC12A2, SLC12A1, SLC26A6, STSextracellular space, cytosolOne of 3 routes

• prostaglandin E2Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of prostaglandin E2 (cytosol to extracellular)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• N-benzoylglycineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• decanoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 8 moreextracellular space, cytosol, mitochondrial matrixOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 11 routes

• L-cysteinylglycineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, GGTLC3 and 5 moreextracellular space, cytosolOne of 6 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosol, mitochondrial matrix

• (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  3. trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase

  Catalysed by SLC12A2, SLC12A1, CLTRN, SLC6A20 and 3 moreextracellular space, cytosolOne of 4 routes

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC4A1extracellular space, cytosolOne of 6 routes

• CHEBI:63544Reach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 10 routes

• docosanoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 9 routes

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, NOS3 and 2 moreextracellular space, cytosol

• Mo-molybdopterinReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC12A2, SLC12A1, SLC6A14, MOCOSextracellular space, cytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 8 routes

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC12A2, SLC12A1, SLC6A14extracellular space, cytosol, endoplasmic reticulum

• (R)-noradrenalineReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of noradrenaline (cytosol to extracellular)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 4 routes