(6R)-10-formyltetrahydrofolate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

97 compounds within 3 steps: 4 in 1, 7 in 2, 86 in 3

Three steps

N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 morecytosol
CHEBI:18381Reach from here →
1. (6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)
2. 5,10-Methenyltetrahydrofolate 5-hydrolase (decyclizing)
3. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
Catalysed by MTHFD1, MTHFD2, MTHFD2L, ATICcytosol
(6S)-5-methyl-5,6,7,8-tetrahydrofolateReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 more
ophthalmateReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 more
N(omega),N('omega)-dimethyl-L-arginineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 more
5,6,7,8-tetrahydrofolic acidReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. 5-formimidoyltetrahydrofolate + L-glutamate = N-formimidoyl-L-glutamate + (6S)-5,6,7,8-tetrahydrofolate
3. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
Catalysed by ALDH1L1, ALDH1L2, FTCDcytosolOne of 9 routes
CHEBI:240943Reach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. glycine N-acyltransferase (2-methylbutyryl-CoA)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 3 moremitochondrial matrix
phenylacetylglycineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. phenylacetyl-CoA:glycine N-phenylacetyltransferase
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 morecytosolOne of 3 routes
CHEBI:28666Reach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. LTD4 hydrolysis
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2cytosol
Gly-tRNA(Gly)Reach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. glycine:tRNA(Gly) ligase (AMP-forming)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 morecytosol
chlorine(.)Reach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of chloride and glycine (cytosol to extracellular)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 2 moreextracellular space, cytosolOne of 3 routes
glycocholateReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. bile acid-CoA: amino acid N-acyltransferase
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 moreperoxisomeOne of 3 routes
5-aminolevulinateReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 2 more
glycochenodeoxycholateReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 more
glycochenodeoxycholic acidReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. bile acid-CoA: amino acid N-acyltransferase
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 moreperoxisomeOne of 3 routes
glyoxylateReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 moreOne of 11 routes
glycolithocholic acidReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. bile acid-CoA:amino acid N-acyltransferase (glycine)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 morecytosolOne of 2 routes
L-2-amino-3-oxobutanoic acidReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. Acetyl-CoA:glycine C-acetyltransferase
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 moremitochondrial matrix
L-ornithineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. L-Arginine:glycine amidinotransferase
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 morecytosolOne of 5 routes
S(8)-aminomethyldihydrolipoamideReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 2 moremitochondrial matrix
sarcosineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 moreOne of 2 routes
7,8-dihydrofolateReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 moreOne of 2 routes
XMPReach from here →
1. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate
2. IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
3. IMP + NAD(+) + H2O = XMP + NADH + H(+)
Catalysed by ATIC, IMPDH2, IMPDH1
N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
1. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate
2. IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
3. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
Catalysed by ATIC, ADSS2, ADSS1
an N-acylglycineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 3 more
dGMPReach from here →
1. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate
2. IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
3. dGMP + inosine = 2'-deoxyguanosine + IMP
Catalysed by ATIC, NT5C2
guanidinoacetateReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. L-Arginine:glycine amidinotransferase
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 morecytosolOne of 2 routes
L-methionineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of glycine and methionine (cytosol to extracellular)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 moreextracellular space, cytosolOne of 5 routes
L-tryptophanReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of glycine and tryptophan (cytosol to extracellular)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 moreextracellular space, cytosolOne of 5 routes
glutathioneReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 more
L-alanineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of alanine and glycine (cytosol to extracellular)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 3 moreextracellular space, cytosolOne of 6 routes
leukotriene C4Reach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. leukotriene C4 hydrolysis
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2cytosol
L-asparagineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of asparagine and glycine (cytosol to extracellular)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2extracellular space, cytosolOne of 4 routes
L-phenylalanineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of glycine and phenylalanine (cytosol to extracellular)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 moreextracellular space, cytosolOne of 7 routes
L-tyrosineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 more
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 more
N-formimidoyl-L-glutamateReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. 5-formimidoyltetrahydrofolate + L-glutamate = N-formimidoyl-L-glutamate + (6S)-5,6,7,8-tetrahydrofolate
3. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
Catalysed by ALDH1L1, ALDH1L2, FTCDcytosol
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 moreOne of 2 routes
N-benzoylglycineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. Hippurate (Benzoylglycinate) Formation
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2mitochondrial matrixOne of 2 routes
dIMPReach from here →
1. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate
2. IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
3. dIMP + inosine = 2'-deoxyinosine + IMP
Catalysed by ATIC, NT5C2
dTMPReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 moreOne of 2 routes
(2S)-2-aminobutanoateReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 more
glycodeoxycholateReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. Glycodeoxycholate amidohydrolase
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2cytosolOne of 2 routes
N-tetradecanoylglycineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 more
N-eicosanoylglycinateReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 more
N-docosanoylglycineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 more
N-hexacosanoylglycineReach from here →
1. (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)
Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2 and 1 more