indole-3-pyruvate

Three steps

• L-methionine (S)-S-oxideReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by AADAT, SLC7A5, MSRAextracellular space, cytosol

• L-methionine (R)-S-oxideReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by AADAT, SLC7A5, MSRB3, MSRB1 and 1 moreextracellular space, cytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by AADAT, SLC7A5, GLYATL2extracellular space, cytosolOne of 2 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by AADAT, SLC7A5, PPCSextracellular space, cytosolOne of 4 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by AADAT, TPH1, TPH2One of 5 routes

• 2-hydroxy-4-methylvaleric acidReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine
  3. 4-methyl-2-oxopentanoate reduction

  Catalysed by AADAT, SDR42E2, AKR1B15, AKR1B10 and 15 morecytosol

• 4-aminobutanoateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by AADAT, SLC6A14, SLC6A12extracellular space, cytosolOne of 4 routes

• 3-iodo-L-tyrosineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of tryptophan and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by AADAT, SLC7A5, TPOextracellular space, cytosolOne of 2 routes

• L-prolineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by AADAT, SLC7A5, SLC1A4extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• estrone 3-sulfateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A24, SLC22A8 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin E2Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. prostaglandin E2(out) + glutarate(in) = prostaglandin E2(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 4 routes

• N-benzoylglycineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by AADAT, SLC7A5extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• 3-sulfino-L-alanineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by AADAT, SLC7A5, CDO1extracellular space, cytosolOne of 6 routes

• L-cysteinylglycineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by AADAT, SLC7A5, GGTLC3, GGT1 and 4 moreextracellular space, cytosolOne of 2 routes

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by AADAT, SLC7A6, NOS3, NOS1 and 1 moreextracellular space, cytosol

• Mo-molybdopterinReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by AADAT, SLC7A5, MOCOSextracellular space, cytosol

• (2S)-2-aminobutanoateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by AADAT, SLC7A5, AGXT2extracellular space, cytosolOne of 7 routes

• 2-iminobutanoateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

  Catalysed by AADAT, AGXT2, RIDA

• 3-phenyllactateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. Formation of Phenyl-Lactate

  Catalysed by AADATcytosol

• thio-Mo-molybdopterinReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by AADAT, SLC7A5, MOCOSextracellular space, cytosol

• 17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• glycodeoxycholateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. Glycodeoxycholate amidohydrolase

  Catalysed by AADAT, SLC7A5extracellular space, cytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by AADAT, SLC7A5, GLYATL2extracellular space, cytosolOne of 2 routes

• N-eicosanoylglycinateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by AADAT, SLC7A5, BAATextracellular space, cytosol

• N-docosanoylglycineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by AADAT, SLC7A5, BAATextracellular space, cytosol

• N-hexacosanoylglycineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by AADAT, SLC7A5, BAATextracellular space, cytosol

• an N(2)-acyl-L-glutamineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by AADAT, SLC7A5, GLYATL1B, GLYATL1extracellular space, cytosol

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by AADAT, AGXT, AGXT2, PDHA1 and 2 moremitochondrial matrix