1-phosphatidyl-1D-myo-inositol

Three steps

• (7Z)-octadecenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 18 morecytosolOne of 3 routes

• CHEBI:15345Reach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 16 morecytosolOne of 2 routes

• cholineReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 16 morecytosol, nucleusOne of 9 routes

• acetylpyruvateReach from here →
  1. phosphatidylinositol N-acetylglucosaminyltransferase (PI pool)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by PIGA, PIGP, PIGH, PIGY and 5 moreendoplasmic reticulum

• pyruvateReach from here →
  1. phosphatidylinositol N-acetylglucosaminyltransferase (PI pool)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by PIGA, PIGP, PIGH, PIGY and 9 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• all-trans-retinoic acidReach from here →
  1. phosphatidylinositol N-acetylglucosaminyltransferase (PI pool)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. transport of acetate and retinoate (cytosol to extracellular)

  Catalysed by PIGA, PIGP, PIGH, PIGY and 7 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• CHEBI:15380Reach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 17 morecytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 18 morecytosol, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 17 morecytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 18 morecytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 16 morecytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 18 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 11 routes

• CHEBI:15519Reach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 18 morecytosol, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 18 morecytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 15 morecytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 18 morecytosolOne of 43 routes

• a 1-hexadecanoyl-2-acylglycerolReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)
  3. a 2-acylglycerol + hexadecanoyl-CoA = a 1-hexadecanoyl-2-acylglycerol + CoA

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 14 morecytosol

• CHEBI:15650Reach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 47 morecytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 16 morecytosol

• CHEBI:15746Reach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 17 morecytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 11 morecytosol, extracellular spaceOne of 12 routes

• keto-D-fructose 6-phosphateReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. inositol-3-phosphate synthase (inositol-1-phosphate)
  3. D-glucose-6-phosphate aldose-ketose-isomerase

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 12 morecytosol

• 11-cis-retinolReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 18 morecytosol

• oxaloacetateReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 16 morecytosol

• N(2)-acetyl-L-ornithineReach from here →
  1. phosphatidylinositol N-acetylglucosaminyltransferase (PI pool)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by PIGA, PIGP, PIGH, PIGY and 5 moreendoplasmic reticulum, cytosol

• CHEBI:16566Reach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
  3. N-acylsphingosine amidohydrolase

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 17 morecytosol

• pregnenoloneReach from here →
  1. ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. 6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 morecytosol, inner side of the membrane, outer side of the membrane

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. ATP:acylglycerol 3-phosphotransferase

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 26 morecytosol, extracellular spaceOne of 6 routes

• a cholesterol esterReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. Phosphatidylcholine:sterol O-acyltransferase

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 13 morecytosolOne of 3 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. phosphatidylinositol N-acetylglucosaminyltransferase (PI pool)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. transport of (R)-3-hydroxybutanoate and acetate (cytosol to extracellular)

  Catalysed by PIGA, PIGP, PIGH, PIGY and 8 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. phosphatidylinositol N-acetylglucosaminyltransferase (PI pool)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by PIGA, PIGP, PIGH, PIGY and 5 moreendoplasmic reticulum

• anilineReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 17 morecytosol

• CHEBI:17312Reach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 15 morecytosolOne of 2 routes

• linoleic acidReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 11 morecytosol, extracellular spaceOne of 12 routes

• cholesteryl 3-beta-D-glucosideReach from here →
  1. ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• 7alpha-hydroxycholesterolReach from here →
  1. ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 morecytosol, inner side of the membrane, outer side of the membrane

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. phosphatidylcholine 2-acylhydrolase

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 30 morecytosol, endoplasmic reticulumOne of 8 routes

• L-cysteineReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 16 morecytosol, mitochondrial matrix

• a sphingomyelinReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. ceramide:phosphatidylcholine cholinephosphotransferase

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 14 morecytosol, Golgi apparatusOne of 13 routes

• 26-hydroxycholesterolReach from here →
  1. ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 26-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 morecytosol, inner side of the membrane, outer side of the membrane

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 18 morecytosol, mitochondrial matrix

• glycerolReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 25 morecytosol, extracellular spaceOne of 2 routes

• 4-methylumbelliferyl acetateReach from here →
  1. phosphatidylinositol N-acetylglucosaminyltransferase (PI pool)
  2. phosphatidylinositol glycan anchor biosynthesis class L
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by PIGA, PIGP, PIGH, PIGY and 7 moreendoplasmic reticulum

• CHEBI:17927Reach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 15 morecytosol

• 4-methylpentanalReach from here →
  1. ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. 6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 morecytosol, inner side of the membrane, outer side of the membrane

• a diacylglycerolReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 34 morecytosolOne of 2 routes

• dodecanoateReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 11 morecytosol, extracellular spaceOne of 12 routes

• phosphatidyl-L-serineReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. CDPethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase
  3. L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 13 morecytosolOne of 2 routes