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Reach

N-dodecanoylglycine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

524 compounds within 3 steps: 4 in 1, 98 in 2, 422 in 3

Does it reach a compound?

Two steps

N-docosanoylglycineReach from here →
1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)
Catalysed by GLYATL2, BAAT
N-hexacosanoylglycineReach from here →
1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)
Catalysed by GLYATL2, BAAT

Three steps

beta-carbolineReach from here →
Catalysed by GLYATL2, SLC7A5extracellular space, cytosol
(S)-carnitineReach from here →
Catalysed by GLYATL2, BAAT and 1 more

Page 3 of 11

, CPT1A

, CPT1C

peroxisome, cytosol

One of 252 routes

3-methyl-2-oxobutanoateReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
transport of glycine and valine (cytosol to extracellular)
L-Valine:2-oxoglutarate aminotransferase

Catalysed by GLYATL2, SLC7A5, BCAT2extracellular space, cytosol, mitochondrial matrixOne of 3 routes

2-phenylpropan-2-olReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O

Catalysed by GLYATL2, GSS, CLIC2, GPX1 and 2 more

a hydroxy polyunsaturated fatty acidReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O

Catalysed by GLYATL2, GSS, GPX1, GPX2 and 1 more

AReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
transport of cysteine and glycine (cytosol to extracellular)
Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by GLYATL2, SLC3A2, SLC7A5, SLC7A8 and 1 moreextracellular space, cytosol

decanoyl-4'-phosphopantetheineReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
Fatty Acid Beta Oxidation (C12->C10), Mitochondrial
decanoyl-CoA + H2O = decanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by GLYATL2, ACADM, ECHS1, ACAA2 and 2 moremitochondrial matrix

tetradecanoyl-4'-phosphopantetheineReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
fatty-acyl-CoA synthase (N-C14:0CoA)
tetradecanoyl-CoA + H2O = tetradecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by GLYATL2, NUDT19, NUDT7cytosol

an acyl-4'-phosphopantetheineReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
acyl-CoA pool formation and breakdown
an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by GLYATL2, NUDT19, FITM2, NUDT8cytosol

tauroursodeoxycholateReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and tauroursodeoxycholate (cytosol to extracellular)

Catalysed by GLYATL2, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycineReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine

Catalysed by GLYATL2, ALOX15, ALOX12

N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycineReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine

Catalysed by GLYATL2, ALOX15B, ALOX15, ALOX12

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O

Catalysed by GLYATL2, GSS, GPX1, GPX4

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
glutathione transferase (GSH)

Catalysed by GLYATL2, GSS, PTGES, MGST3 and 19 morecytosolOne of 5 routes

prostaglandin E3Reach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and prostaglandin E3 (cytosol to extracellular)

Catalysed by GLYATL2, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

prostaglandin A2Reach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and prostaglandin A2 (cytosol to extracellular)

Catalysed by GLYATL2, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

prostaglandin B1Reach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and prostaglandin B1 (cytosol to extracellular)

Catalysed by GLYATL2, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

leukotriene F4Reach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and leukotriene F4 (cytosol to extracellular)

Catalysed by GLYATL2, GSScytosol, extracellular spaceOne of 4 routes

prostaglandin A2-S-(R)-glutathioneReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

Catalysed by GLYATL2, GSS, GSTA1, GSTM1

prostaglandin A2-S-(S)-glutathioneReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

Catalysed by GLYATL2, GSS, GSTP1, GSTM1

prostaglandin J2-S-(R)-glutathioneReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione

Catalysed by GLYATL2, GSS, GSTA1, GSTP1 and 1 more

prostaglandin J2-S-(S)-glutathioneReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione

Catalysed by GLYATL2, GSS, GSTP1, GSTM1

2,4-dinitrophenyl-S-glutathioneReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
bile acid-CoA: amino acid N-acyltransferase
solute carrier organic anion transporter (glycocholate)

Catalysed by GLYATL2, BAAT, SLCO1A2, SLCO1B3peroxisome, extracellular space, cytosolOne of 11 routes

N-(9Z-octadecenoyl)-L-phenylalanineReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
transport of glycine and phenylalanine (cytosol to extracellular)
L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

Catalysed by GLYATL2, SLC7A5, PM20D1extracellular space, cytosol

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
transport of glycine and phenylalanine (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

Catalysed by GLYATL2, SLC7A5, PM20D1extracellular space, cytosol

N-(9Z-octadecenoyl)-L-leucineReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
transport of glycine and leucine (cytosol to extracellular)
N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

Catalysed by GLYATL2, SLC7A5, PM20D1extracellular space, cytosol

(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate

Catalysed by GLYATL2, GSS, GSTM4, LTC4S

2-hydroxydecanoyl-CoAReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
Fatty Acid Beta Oxidation (C12->C10), Mitochondrial
decanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydecanoyl-CoA + succinate + CO2

Catalysed by GLYATL2, ACADM, ECHS1, ACAA2 and 2 moremitochondrial matrix

2-hydroxytetradecanoyl-CoAReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
fatty-acyl-CoA synthase (N-C14:0CoA)
tetradecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxytetradecanoyl-CoA + succinate + CO2

Catalysed by GLYATL2, PHYHcytosol

11-cis-retinyl tetradecanoateReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
fatty-acyl-CoA synthase (N-C14:0CoA)
11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA

Catalysed by GLYATL2, AWAT2cytosol

9-cis-retinyl tetradecanoateReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
fatty-acyl-CoA synthase (N-C14:0CoA)
9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA

Catalysed by GLYATL2, AWAT2cytosol

13-cis-retinyl tetradecanoateReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
fatty-acyl-CoA synthase (N-C14:0CoA)
13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA

Catalysed by GLYATL2, AWAT2cytosol

all-trans-retinyl tetradecanoateReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
fatty-acyl-CoA synthase (N-C14:0CoA)
all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA

Catalysed by GLYATL2, AWAT2cytosol

tetradecyl tetradecanoateReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
fatty-acyl-CoA synthase (N-C14:0CoA)
tetradecan-1-ol + tetradecanoyl-CoA = tetradecyl tetradecanoate + CoA

Catalysed by GLYATL2, AWAT2cytosol

S-methyl glutathioneReach from here →

dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

Catalysed by GLYATL2, GSS, MMACHC

N-octanoyl-(2S)-hydroxyglycineReach from here →

N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O