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Proteins/UNIPROT:P52569
Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing. May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity)..
[Isoform 1]: Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine and L-homoarginine than isoform 2..
[Isoform 2]: Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine)..
Function from UniProtKB (P52569), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
24 statements
24 statements · 6 reference databases · Subject: SLC7A2 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Rhea, WikiPathways
9 reactions
Transported by SLC7A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04849CC BY 4.0Reference data
Transported by SLC7A2 or SLC38A4 or SLC7A1 or SLC7A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05068CC BY 4.0Reference data
5 names
Resolves to: SLC7A2
Transported by SLC3A2 & SLC7A8 or SLC7A2 or SLC7A5 or SLC36A1 or SLC7A7 or SLC7A3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05070CC BY 4.0Reference data
Transported by SLC7A2 or SLC7A1 or SLC7A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05071CC BY 4.0Reference data
Transported by SLC7A2 or SLC38A4 or SLC7A1 or SLC7A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05094CC BY 4.0Reference data
Transported by SLC38A8 or SLC7A1 or CHRNA7 or SLC7A2 or SLCO4C1 or SLC25A29 or SLC7A3 or SLC25A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:32143CC BY 4.0Reference data
Transported by SLC7A1 or SLC7A2 or SLC25A29 or SLC7A3 or SLC25A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:70935CC BY 4.0Reference data
Transported by SLC7A1 or SLC7A2 or SLC25A29 or SLC7A3 or SLC25A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:71199CC BY 4.0Reference data
Transported by SLC7A1 or SLC7A2 or SLCO4C1
Reaction pageDirection not assertedBalanced
Rhea RHEA:71203CC BY 4.0Reference data