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Proteins/UNIPROT:Q8IVB4
Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (Probable). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, e.g., endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters. Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain. Regulates synaptic transmission by regulating the luminal pH of axonal endosomes (By similarity). Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages (By similarity). Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracellular pH (By similarity)..
Function from UniProtKB (Q8IVB4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
17 statements
17 statements · 6 reference databases · Subject: SLC9A9 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea
3 reactions
proton+sodium(1+)proton+sodium(1+)
Transported by SLC9A3 or SLC9A1 or SLC9A2 or SLC9A5 or SLC9A4 or SLC9A9
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05430CC BY 4.0Reference data
4 names
Resolves to: SLC9A9
Transported by SLC9A1 or SLC9A3 or SLC9A5 or SLC9A4 or SLC9B2 or SLC9A9 or SLC9A6 or SLC9A7 or SLC9A2 or SLC9A8
Reaction pageReversibleBalanced
Rhea RHEA:29419CC BY 4.0Reference data