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Proteins/UNIPROT:Q8IY81
RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation..
(Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system. RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5. Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine. Recruited to HIV-1 RNA via interaction with TARBP2/TRBP..
Function from UniProtKB (Q8IY81), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
55 statements
55 statements · 3 reference databases · Subject: FTSJ3 · Sources: Hetionet, Human Protein Atlas, Reactome
2 reactions
a ribonucleotide in rRNA+S-adenosyl-L-methioninea 2'-O-methylribonucleotide in rRNA+S-adenosyl-L-homocysteine+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:48628CC BY 4.0Reference data
a ribonucleotide in RNA+S-adenosyl-L-methioninea 2'-O-methylribonucleotide in RNA+S-adenosyl-L-homocysteine+hydron
Catalysed by FBLL1
3 names
Resolves to: FTSJ3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:58956CC BY 4.0Reference data