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Proteins/UNIPROT:O60478
Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomal localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy..
Also acts as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity)..
Function from UniProtKB (O60478), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
24 statements
24 statements · 2 reference databases · Subject: GPR137B · Sources: gene ontology, Hetionet
3 names
Resolves to: GPR137B