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Proteins/UNIPROT:Q9UBY0
Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (By similarity)..
Function from UniProtKB (Q9UBY0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
19 statements
19 statements · 5 reference databases · Subject: SLC9A2 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea
3 reactions
sodium(1+)+ammoniumsodium(1+)+ammonium
Transported by SLC9A3 or SLC9A1 or SLC9A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR01528CC BY 4.0Reference data
4 names
Resolves to: SLC9A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05430CC BY 4.0Reference data
sodium(1+)+hydronsodium(1+)+hydron
Transported by SLC9A1 or SLC9A3 or SLC9A5 or SLC9A4 or SLC9B2 or SLC9A9 or SLC9A6 or SLC9A7 or SLC9A2 or SLC9A8
Reaction pageReversibleBalanced
Rhea RHEA:29419CC BY 4.0Reference data