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Proteins/UNIPROT:Q86UD5
Electroneutral Na(+) Li(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane. Uses the proton gradient/membrane potential to extrude sodium. Contributes to the regulation of intracellular pH and sodium homeostasis (By similarity). Also able to mediate Na(+)/Li(+) antiporter activity in kidney. May play a physiological role in renal tubular function and blood pressure homeostasis (By similarity). Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity)..
Function from UniProtKB (Q86UD5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
17 statements
17 statements · 4 reference databases · Subject: SLC9B2 · Sources: gene ontology, Hetionet, Reactome, Rhea
3 reactions
sodium(1+)+hydronsodium(1+)+hydron
Transported by SLC9A1 or SLC9A3 or SLC9A5 or SLC9A4 or SLC9B2 or SLC9A9 or SLC9A6 or SLC9A7 or SLC9A2 or SLC9A8
Reaction pageReversibleBalanced
Rhea RHEA:29419CC BY 4.0Reference data
7 names
Resolves to: SLC9B2
Reaction pageDirection not assertedBalanced
Rhea RHEA:72407CC BY 4.0Reference data
Li(+)+sodium(1+)Li(+)+sodium(1+)
Transported by SLC9A1 or SLC9B2
Reaction pageDirection not assertedBalanced
Rhea RHEA:72415CC BY 4.0Reference data