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Proteins/UNIPROT:P06727

APOA4

Protein·UNIPROT:P06727

Open in the graph

May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

Function from UniProtKB (P06727), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

hereditary amyloidosis has a germline basis in APOA4DiseaseGenCC HGNC:602|MONDO:0018634Inferred only

Statements

38 statements

38 statements · 4 reference databases · Subject: APOA4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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APOB covaries with APOA4ProteinHetionet hetionet:covaries:337-338Inferred only
APOA4 covaries with CLCA2ProteinHetionet hetionet:covaries:337-9635Inferred only
ERCC1 covaries with APOA4ProteinHetionet hetionet:covaries:2067-337Inferred only
LY6G5B covaries with APOA4ProteinHetionet hetionet:covaries:337-58496Inferred only
MRPL52 covaries with APOA4ProteinHetionet hetionet:covaries:122704-337Inferred only
OR13C2 covaries with APOA4ProteinHetionet hetionet:covaries:337-392376Inferred only
PELI2 covaries with APOA4ProteinHetionet hetionet:covaries:337-57161Inferred only
APOA4 covaries with SLC9A1ProteinHetionet hetionet:covaries:337-6548Inferred only
TENT4B covaries with APOA4ProteinHetionet hetionet:covaries:337-64282Inferred only
APOA4 interacts with GPLD1ProteinHetionet hetionet:interacts:2822-337Inferred only
APOA4 participates in Amyloid fiber formationPathwayReactome R-HSA-977225Inferred only
APOA4 participates in Assembly of active LPL and LIPC lipase complexesPathwayReactome R-HSA-8963889Inferred only

Show the remaining 26

APOA4 participates in Cholesterol metabolismPathwayWikiPathways WP5304Inferred only
APOA4 participates in Chylomicron assemblyPathwayReactome R-HSA-8963888Inferred only
APOA4 participates in Chylomicron remodelingPathwayReactome R-HSA-8963901Inferred only
APOA4 participates in Enterocyte cholesterol metabolismPathwayWikiPathways WP5333Inferred only
APOA4 participates in Familial hyperlipidemia type 1PathwayWikiPathways WP5108Inferred only
APOA4 participates in Familial hyperlipidemia type 2PathwayWikiPathways WP5109Inferred only
APOA4 participates in Familial hyperlipidemia type 3PathwayWikiPathways WP5110Inferred only
APOA4 participates in Familial hyperlipidemia type 4PathwayWikiPathways WP5111Inferred only
APOA4 participates in Familial hyperlipidemia type 5PathwayWikiPathways WP5112Inferred only
APOA4 participates in Fatty acid and lipoprotein transport in hepatocytesPathwayWikiPathways WP5323Inferred only
APOA4 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
APOA4 participates in Metabolism of fat-soluble vitaminsPathwayReactome R-HSA-6806667Inferred only
APOA4 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
APOA4 participates in Metabolism of vitamins and cofactorsPathwayReactome R-HSA-196854Inferred only
APOA4 participates in Plasma lipoprotein assemblyPathwayReactome R-HSA-8963898Inferred only
APOA4 participates in Plasma lipoprotein assembly, remodeling, and clearancePathwayReactome R-HSA-174824Inferred only
APOA4 participates in Plasma lipoprotein remodelingPathwayReactome R-HSA-8963899Inferred only
APOA4 participates in Retinoid metabolism and transportPathwayReactome R-HSA-975634Inferred only
APOA4 participates in Sensory PerceptionPathwayReactome R-HSA-9709957Inferred only
APOA4 participates in Statin inhibition of cholesterol productionPathwayWikiPathways WP430Inferred only
APOA4 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
APOA4 participates in Visual phototransductionPathwayReactome R-HSA-2187338Inferred only
APOA4 regulates negative regulation of plasma lipoprotein oxidationBiological processgene ontology P06727|GO:0034445Inferred only
APOA4 regulates positive regulation of fatty acid biosynthetic processBiological processgene ontology P06727|GO:0045723Inferred only
APOA4 regulates positive regulation of triglyceride catabolic processBiological processgene ontology P06727|GO:0010898Inferred only
APOA4 regulates regulation of cholesterol transportBiological processgene ontology P06727|GO:0032374Inferred only

Other names

3 names

Resolves to: APOA4

Also called: Apo-AIVApoA-IVApolipoprotein A4

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