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Proteins/UNIPROT:Q14940
Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues. Acts as a negative regulator of dendritic spine growth. Plays a role in postsynaptic remodeling and signaling. Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking..
Function from UniProtKB (Q14940), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 5 reference databases · Subject: SLC9A5 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea
2 reactions
proton+sodium(1+)proton+sodium(1+)
Transported by SLC9A3 or SLC9A1 or SLC9A2 or SLC9A5 or SLC9A4 or SLC9A9
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05430CC BY 4.0Reference data
4 names
Resolves to: SLC9A5
Transported by SLC9A1 or SLC9A3 or SLC9A5 or SLC9A4 or SLC9B2 or SLC9A9 or SLC9A6 or SLC9A7 or SLC9A2 or SLC9A8
Reaction pageReversibleBalanced
Rhea RHEA:29419CC BY 4.0Reference data