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Proteins/UNIPROT:P49354
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation..
Function from UniProtKB (P49354), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
225 statements
225 statements · 8 reference databases · Subject: FNTA · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
MAM00200c+(2E,6E)-farnesyl diphosphatediphosphate(3-)+MAM02898c
Reaction pageLeft to rightBalance undeterminableEC 2.5.1.58cytosol
Human-GEM MAR07166CC BY 4.0Reference data
L-cysteinyl-[protein]+(2E,6E)-farnesyl diphosphateS-(2E,6E)-farnesyl-L-cysteinyl-[protein]+diphosphate(3-)
Reaction pageDirection not asserted
5 names
Resolves to: FNTA
Rhea RHEA:13345CC BY 4.0Reference data
CHEBI:57533+L-cysteinyl-[protein]S-geranylgeranyl-L-cysteinyl-[protein]+diphosphate(3-)
Catalysed by FNTA or PGGT1B or RABGGTB or RABGGTA
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:21240CC BY 4.0Reference data