Proteins/UNIPROT:P35249

RFC4

ProteinUNIPROT:P35249

Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. The RFC4 subunit probably functions as a scaffold on which the other complex components can assemble..

Function from UniProtKB (P35249), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Morimoto-Ryu-Malicdan neuromuscular syndrome has a germline basis in RFC4DiseaseGenCC HGNC:9972|MONDO:0975848Inferred only

Statements

114 statements

114 statements · 4 reference databases · Subject: RFC4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

RFC4 interacts with BRD4ProteinHetionet hetionet:interacts:23476-5984Inferred only
CDK4 interacts with RFC4ProteinHetionet hetionet:interacts:1019-5984Inferred only
RFC4 interacts with CHTF18ProteinHetionet hetionet:interacts:5984-63922Inferred only
HDAC1 interacts with RFC4ProteinHetionet hetionet:interacts:3065-5984Inferred only
HDGF interacts with RFC4ProteinHetionet hetionet:interacts:3068-5984Inferred only
RFC4 interacts with MEPCEProteinHetionet hetionet:interacts:56257-5984Inferred only
RFC4 interacts with PAXIP1ProteinHetionet hetionet:interacts:22976-5984Inferred only
PCNA interacts with RFC4ProteinHetionet hetionet:interacts:5111-5984Inferred only
RAD17 interacts with RFC4ProteinHetionet hetionet:interacts:5884-5984Inferred only
RFC1 interacts with RFC4ProteinHetionet hetionet:interacts:5981-5984Inferred only
RFC2 interacts with RFC4ProteinHetionet hetionet:interacts:5982-5984Inferred only
RFC3 interacts with RFC4ProteinHetionet hetionet:interacts:5983-5984Inferred only

Show the remaining 102

RFC4 interacts with RFC5ProteinHetionet hetionet:interacts:5984-5985Inferred only
RFC4 interacts with RNF41ProteinHetionet hetionet:interacts:10193-5984Inferred only
RFC4 interacts with UBCProteinHetionet hetionet:interacts:5984-7316Inferred only
RFC4 interacts with YWHAZProteinHetionet hetionet:interacts:5984-7534Inferred only
RFC4 participates in Activation of ATR in response to replication stressPathwayReactome R-HSA-176187Inferred only
RFC4 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
RFC4 participates in Affinity selection of immunoglobulinsPathwayReactome R-HSA-9938027Inferred only
RFC4 participates in Base excision repairPathwayWikiPathways WP4752Inferred only
RFC4 participates in Base Excision RepairPathwayReactome R-HSA-73884Inferred only
RFC4 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
RFC4 participates in Cell Cycle CheckpointsPathwayReactome R-HSA-69620Inferred only
RFC4 participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
RFC4 participates in Chromosome MaintenancePathwayReactome R-HSA-73886Inferred only
RFC4 participates in Defective homologous recombination repair (HRR) due to BRCA2 loss of functionPathwayReactome R-HSA-9701190Inferred only
RFC4 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
RFC4 participates in Diseases of DNA Double-Strand Break RepairPathwayReactome R-HSA-9675136Inferred only
RFC4 participates in Diseases of DNA repairPathwayReactome R-HSA-9675135Inferred only
RFC4 participates in DNA Damage BypassPathwayReactome R-HSA-73893Inferred only
RFC4 participates in DNA Double-Strand Break RepairPathwayReactome R-HSA-5693532Inferred only
RFC4 participates in DNA mismatch repairPathwayWikiPathways WP531Inferred only
RFC4 participates in DNA RepairPathwayReactome R-HSA-73894Inferred only
RFC4 participates in DNA replicationPathwayWikiPathways WP466Inferred only
RFC4 participates in DNA ReplicationPathwayReactome R-HSA-69306Inferred only
RFC4 participates in DNA strand elongationPathwayReactome R-HSA-69190Inferred only
RFC4 participates in Dual Incision in GG-NERPathwayReactome R-HSA-5696400Inferred only
RFC4 participates in Dual incision in TC-NERPathwayReactome R-HSA-6782135Inferred only
RFC4 participates in Extension of TelomeresPathwayReactome R-HSA-180786Inferred only
RFC4 participates in G2/M CheckpointsPathwayReactome R-HSA-69481Inferred only
RFC4 participates in G2/M DNA damage checkpointPathwayReactome R-HSA-69473Inferred only
RFC4 participates in Gap-filling DNA repair synthesis and ligation in GG-NERPathwayReactome R-HSA-5696397Inferred only
RFC4 participates in Gap-filling DNA repair synthesis and ligation in TC-NERPathwayReactome R-HSA-6782210Inferred only
RFC4 participates in Gastric cancer network 2PathwayWikiPathways WP2363Inferred only
RFC4 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
RFC4 participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
RFC4 participates in Genes and complexes involved in the DNA repair pathwaysPathwayWikiPathways WP4946Inferred only
RFC4 participates in Global Genome Nucleotide Excision Repair (GG-NER)PathwayReactome R-HSA-5696399Inferred only
RFC4 participates in HDR through Homologous Recombination (HRR)PathwayReactome R-HSA-5685942Inferred only
RFC4 participates in HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)PathwayReactome R-HSA-5693567Inferred only
RFC4 participates in HDR through Single Strand Annealing (SSA)PathwayReactome R-HSA-5685938Inferred only
RFC4 participates in Homologous DNA Pairing and Strand ExchangePathwayReactome R-HSA-5693579Inferred only
RFC4 participates in Homology Directed RepairPathwayReactome R-HSA-5693538Inferred only
RFC4 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
RFC4 participates in Immunoglobulin maturationPathwayReactome R-HSA-9938026Inferred only
RFC4 participates in Impaired BRCA2 binding to RAD51PathwayReactome R-HSA-9709570Inferred only
RFC4 participates in Lagging Strand SynthesisPathwayReactome R-HSA-69186Inferred only
RFC4 participates in Leading Strand SynthesisPathwayReactome R-HSA-69109Inferred only
RFC4 participates in NF1 copy number variation syndrome PathwayWikiPathways WP5366Inferred only
RFC4 participates in Nucleotide excision repairPathwayWikiPathways WP4753Inferred only
RFC4 participates in Nucleotide Excision RepairPathwayReactome R-HSA-5696398Inferred only
RFC4 participates in Nucleotide excision repair in xeroderma pigmentosum PathwayWikiPathways WP5114Inferred only
RFC4 participates in PCNA-Dependent Long Patch Base Excision RepairPathwayReactome R-HSA-5651801Inferred only
RFC4 participates in Polymerase switchingPathwayReactome R-HSA-69091Inferred only
RFC4 participates in Polymerase switching on the C-strand of the telomerePathwayReactome R-HSA-174411Inferred only
RFC4 participates in Presynaptic phase of homologous DNA pairing and strand exchangePathwayReactome R-HSA-5693616Inferred only
RFC4 participates in Processing of DNA double-strand break endsPathwayReactome R-HSA-5693607Inferred only
RFC4 participates in Recognition of DNA damage by PCNA-containing replication complexPathwayReactome R-HSA-110314Inferred only
RFC4 participates in Regulation of TP53 ActivityPathwayReactome R-HSA-5633007Inferred only
RFC4 participates in Regulation of TP53 Activity through PhosphorylationPathwayReactome R-HSA-6804756Inferred only
RFC4 participates in Resolution of Abasic Sites (AP sites)PathwayReactome R-HSA-73933Inferred only
RFC4 participates in Resolution of AP sites via the multiple-nucleotide patch replacement pathwayPathwayReactome R-HSA-110373Inferred only
RFC4 participates in Retinoblastoma gene in cancerPathwayWikiPathways WP2446Inferred only
RFC4 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
RFC4 participates in S PhasePathwayReactome R-HSA-69242Inferred only
RFC4 participates in Somatic hypermutation of immunoglobulin genesPathwayReactome R-HSA-9938024Inferred only
RFC4 participates in Somatic hypermutation of immunoglobulin genes by error-prone base excision repair (BER)PathwayReactome R-HSA-9968297Inferred only
RFC4 participates in Somatic hypermutation of immunoglobulin genes by error-prone mismatch repair (MMR)PathwayReactome R-HSA-9968295Inferred only
RFC4 participates in Synthesis of DNAPathwayReactome R-HSA-69239Inferred only
RFC4 participates in Telomere C-strand (Lagging Strand) SynthesisPathwayReactome R-HSA-174417Inferred only
RFC4 participates in Telomere MaintenancePathwayReactome R-HSA-157579Inferred only
RFC4 participates in Termination of translesion DNA synthesisPathwayReactome R-HSA-5656169Inferred only
RFC4 participates in Transcription-Coupled Nucleotide Excision Repair (TC-NER)PathwayReactome R-HSA-6781827Inferred only
RFC4 participates in Transcriptional Regulation by TP53PathwayReactome R-HSA-3700989Inferred only
RFC4 participates in Translesion Synthesis by POLHPathwayReactome R-HSA-110320Inferred only
RFC4 participates in Translesion synthesis by POLIPathwayReactome R-HSA-5656121Inferred only
RFC4 participates in Translesion synthesis by POLKPathwayReactome R-HSA-5655862Inferred only
RFC4 participates in Translesion synthesis by REV1PathwayReactome R-HSA-110312Inferred only
RFC4 participates in Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templatePathwayReactome R-HSA-110313Inferred only
RFC4 regulates positive regulation of DNA-directed DNA polymerase activityBiological processgene ontology P35249|GO:1900264Inferred only
ATP1B1 decreases the expression of RFC4ProteinHetionet hetionet:regulates:481-5984Inferred only
CASP3 decreases the expression of RFC4ProteinHetionet hetionet:regulates:836-5984Inferred only
CDKN2C decreases the expression of RFC4ProteinHetionet hetionet:regulates:1031-5984Inferred only
CRADD decreases the expression of RFC4ProteinHetionet hetionet:regulates:8738-5984Inferred only
DDX10 decreases the expression of RFC4ProteinHetionet hetionet:regulates:1662-5984Inferred only
DLX2 decreases the expression of RFC4ProteinHetionet hetionet:regulates:1746-5984Inferred only
DNTTIP2 decreases the expression of RFC4ProteinHetionet hetionet:regulates:30836-5984Inferred only
DYNLL1 decreases the expression of RFC4ProteinHetionet hetionet:regulates:8655-5984Inferred only
GATB decreases the expression of RFC4ProteinHetionet hetionet:regulates:5188-5984Inferred only
GPER1 decreases the expression of RFC4ProteinHetionet hetionet:regulates:2852-5984Inferred only
HNF4A decreases the expression of RFC4ProteinHetionet hetionet:regulates:3172-5984Inferred only
ID2 decreases the expression of RFC4ProteinHetionet hetionet:regulates:3398-5984Inferred only
IL1RAP increases the expression of RFC4ProteinHetionet hetionet:regulates:3556-5984Inferred only
KDELR3 decreases the expression of RFC4ProteinHetionet hetionet:regulates:11015-5984Inferred only
MAP4K4 decreases the expression of RFC4ProteinHetionet hetionet:regulates:9448-5984Inferred only
POU5F1 decreases the expression of RFC4ProteinHetionet hetionet:regulates:5460-5984Inferred only
PRMT7 decreases the expression of RFC4ProteinHetionet hetionet:regulates:54496-5984Inferred only
PSMD2 decreases the expression of RFC4ProteinHetionet hetionet:regulates:5708-5984Inferred only
RAD51 decreases the expression of RFC4ProteinHetionet hetionet:regulates:5888-5984Inferred only
SETMAR decreases the expression of RFC4ProteinHetionet hetionet:regulates:6419-5984Inferred only
SPR decreases the expression of RFC4ProteinHetionet hetionet:regulates:6697-5984Inferred only
TP53BP1 increases the expression of RFC4ProteinHetionet hetionet:regulates:7158-5984Inferred only
TRAF1 decreases the expression of RFC4ProteinHetionet hetionet:regulates:7185-5984Inferred only
UGCG decreases the expression of RFC4ProteinHetionet hetionet:regulates:7357-5984Inferred only

Other names

6 names

Resolves to: RFC4

Also called: A1 37 kDa subunitActivator 1 37 kDa subunitActivator 1 subunit 4Replication factor C 37 kDa subunitRF-C 37 kDa subunitRFC37

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