CFDP1

Required for the structural stability of pericentromeric heterochromatin. Regulates heterochromatin state by stabilizing CBX5/HP1alpha and H3K9me3 at major satellites and CENPA at minor satellites and is required for incorporation of histone H2AZ1/H2AZ into chromatin (By similarity). Maintenance of chromatin structure promotes binding of guanine-nucleotide releasing factor RCC1 to minor and major satellite repeats (By similarity). Chromatin-bound RCC1 maintains high levels of GTP-bound RAN near the centromeric heterochromatin, facilitating RAN-mediated microtubule nucleation during mitosis (By similarity). Plays a role in craniofacial development (By similarity). Required to maintain normal cell function in embryonic development (By similarity)..

Function from UniProtKB (Q9UEE9), read 2026-09-23. CC BY 4.0.