Loading the page.
Proteins/UNIPROT:P36957
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A..
Function from UniProtKB (P36957), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
150 statements
150 statements · 7 reference databases · Subject: DLST · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, UniProt, WikiPathways
4 reactions
MAM02393m+MAM20077mMAM02899m+thiamine(1+) diphosphate
Catalysed by DLST & OGDH or DLST & DHTKD1
Reaction pageLeft to rightBalance undeterminableEC 1.2.4.2mitochondrial matrix
Human-GEM MAR04599CC BY 4.0Reference data
CHEBI:1146900+MAM02934mMAM01701m+CHEBI:15380
Catalysed by DLST
Reaction pageReversibleBalancedEC 2.3.1.61
5 names
Resolves to: DLST
Human-GEM MAR06414CC BY 4.0Reference data
CHEBI:1146900+MAM02899mMAM01701m+glutaryl-CoA
Catalysed by DLST
Reaction pageLeft to rightBalancedEC 2.3.1.61mitochondrial matrix
Human-GEM MAR06415CC BY 4.0Reference data
N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein]+succinyl-CoAN(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein]+coenzyme A(4-)
Catalysed by DLST
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:15213CC BY 4.0Reference data