Proteins/UNIPROT:Q6PJP8

DCLRE1A

ProteinUNIPROT:Q6PJP8

May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem)..

Function from UniProtKB (Q6PJP8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

27 statements

27 statements · 3 reference databases · Subject: DCLRE1A · Sources: Hetionet, Reactome, WikiPathways

Order

FBXO43 covaries with DCLRE1AProteinHetionet hetionet:covaries:286151-9937Inferred only
GSDMB covaries with DCLRE1AProteinHetionet hetionet:covaries:55876-9937Inferred only
HEPN1 covaries with DCLRE1AProteinHetionet hetionet:covaries:641654-9937Inferred only
ZSCAN12 covaries with DCLRE1AProteinHetionet hetionet:covaries:9753-9937Inferred only
ATM interacts with DCLRE1AProteinHetionet hetionet:interacts:472-9937Inferred only
PCNA interacts with DCLRE1AProteinHetionet hetionet:interacts:5111-9937Inferred only
PIAS1 interacts with DCLRE1AProteinHetionet hetionet:interacts:8554-9937Inferred only
TP53BP1 interacts with DCLRE1AProteinHetionet hetionet:interacts:7158-9937Inferred only
UBC interacts with DCLRE1AProteinHetionet hetionet:interacts:7316-9937Inferred only
DCLRE1A participates in DNA IR damage and cellular response via ATRPathwayWikiPathways WP4016Inferred only
DCLRE1A participates in DNA RepairPathwayReactome R-HSA-73894Inferred only
DCLRE1A participates in Fanconi Anemia PathwayPathwayReactome R-HSA-6783310Inferred only

Show the remaining 15

AKR1A1 decreases the expression of DCLRE1AProteinHetionet hetionet:regulates:10327-9937Inferred only
CRADD decreases the expression of DCLRE1AProteinHetionet hetionet:regulates:8738-9937Inferred only
EGR1 decreases the expression of DCLRE1AProteinHetionet hetionet:regulates:1958-9937Inferred only
HDAC6 increases the expression of DCLRE1AProteinHetionet hetionet:regulates:10013-9937Inferred only
HIF1AN increases the expression of DCLRE1AProteinHetionet hetionet:regulates:55662-9937Inferred only
IMPA1 decreases the expression of DCLRE1AProteinHetionet hetionet:regulates:3612-9937Inferred only
JMJD4 increases the expression of DCLRE1AProteinHetionet hetionet:regulates:65094-9937Inferred only
POLD1 increases the expression of DCLRE1AProteinHetionet hetionet:regulates:5424-9937Inferred only
POLR3B increases the expression of DCLRE1AProteinHetionet hetionet:regulates:55703-9937Inferred only
PRMT7 increases the expression of DCLRE1AProteinHetionet hetionet:regulates:54496-9937Inferred only
RPS6KA2 increases the expression of DCLRE1AProteinHetionet hetionet:regulates:6196-9937Inferred only
SETMAR increases the expression of DCLRE1AProteinHetionet hetionet:regulates:6419-9937Inferred only
SIRT1 increases the expression of DCLRE1AProteinHetionet hetionet:regulates:23411-9937Inferred only
SLC38A3 increases the expression of DCLRE1AProteinHetionet hetionet:regulates:10991-9937Inferred only
UBC decreases the expression of DCLRE1AProteinHetionet hetionet:regulates:7316-9937Inferred only

Reactions

1 reaction

CHEBI:35627+waterCHEBI:140347
Catalysed by DPEP1 or MBLAC2 or DCLRE1A or DCLRE1B
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:20401CC BY 4.0Reference data

Other names

7 names

Resolves to: DCLRE1A

Also called: Beta-lactamase DCLRE1AhSNM1hSNM1AKIAA0086SNM1SNM1 homolog ASNM1A

← Every protein Find it in the graph →