Loading the page.
Proteins/UNIPROT:O94911
[Isoform 1]: Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate. In vitro, also imports ochratoxin A. Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes..
[Isoform 3]: Catalyzes ATP-dependent efflux of cholesterol and taurocholate. Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels..
Function from UniProtKB (O94911), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
67 statements
67 statements · 7 reference databases · Subject: ABCA8 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
10 reactions
ATP+17beta-estradiol 3-O-(beta-D-glucuronate)+waterADP+17beta-estradiol 3-O-(beta-D-glucuronate)+proton+phosphate(3-)
Transported by ABCA8
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09879CC BY 4.0Reference data
2 names
Resolves to: ABCA8
Transported by ABCA8
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09881CC BY 4.0Reference data
ATP+water+leukotriene C4ADP+proton+leukotriene C4+phosphate(3-)
Transported by ABCA8
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09893CC BY 4.0Reference data
ATP+water+taurocholateADP+proton+phosphate(3-)+taurocholate
Transported by ABCA8
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09906CC BY 4.0Reference data
cholesterol+ATP(4-)+watercholesterol+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCA8 or ABCA1 or ABCG1 or ABCA13 or ABCA5 or ABCA3 or ABCG4 or ABCG8 or ABCG5
Reaction pageLeft to rightBalanced
Rhea RHEA:39051CC BY 4.0Reference data
taurocholate+ATP(4-)+watertaurocholate+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC3 or ABCA8 or ABCB11 or ABCC11
Reaction pageLeft to rightBalanced
Rhea RHEA:50052CC BY 4.0Reference data
estrone 3-sulfate+ATP(4-)+waterestrone 3-sulfate+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCA8
Reaction pageLeft to rightBalanced
Rhea RHEA:65956CC BY 4.0Reference data
leukotriene C4+ATP(4-)+waterleukotriene C4+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCA8
Reaction pageLeft to rightBalanced
Rhea RHEA:65960CC BY 4.0Reference data
taurocholate+ATP(4-)+watertaurocholate+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCA8
Reaction pageLeft to rightBalanced
Rhea RHEA:65964CC BY 4.0Reference data
17beta-estradiol 17-O-(beta-D-glucuronate)+ATP(4-)+water17beta-estradiol 17-O-(beta-D-glucuronate)+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCA8
Reaction pageLeft to rightBalanced
Rhea RHEA:65968CC BY 4.0Reference data