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Proteins/UNIPROT:Q9H9B4
Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine..
Function from UniProtKB (Q9H9B4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
29 statements
29 statements · 5 reference databases · Subject: SFXN1 · Sources: Bgee, Hetionet, Human-GEM, Rhea, WikiPathways
5 reactions
Transported by SFXN1
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR05113CC BY 4.0Reference data
L-seryl residueL-seryl residue
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR05114CC BY 4.0Reference data
1 name
Resolves to: SFXN1
Reaction pageLeft to rightBalanced
Rhea RHEA:29655CC BY 4.0Reference data
L-seryl residueL-seryl residue
Transported by SFXN2 or SFXN3 or SFXN1 or SLC38A10
Reaction pageLeft to rightBalanced
Rhea RHEA:35031CC BY 4.0Reference data
Transported by SLC38A8 or SLC7A5 or SLC36A4 or SFXN1 or SLC38A10
Reaction pageReversibleBalanced
Rhea RHEA:70719CC BY 4.0Reference data