Proteins/UNIPROT:Q15120

PDK3

ProteinUNIPROT:Q15120

Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species..

Function from UniProtKB (Q15120), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Charcot-Marie-Tooth disease X-linked dominant 6 has a germline basis in PDK3DiseaseGenCC HGNC:8811|MONDO:0010479Inferred only

Statements

26 statements

26 statements · 3 reference databases · Subject: PDK3 · Sources: gene ontology, Hetionet, Reactome

Order

PDK3 covaries with H2AC25ProteinHetionet hetionet:covaries:5165-92815Inferred only
APP interacts with PDK3ProteinHetionet hetionet:interacts:351-5165Inferred only
DLAT interacts with PDK3ProteinHetionet hetionet:interacts:1737-5165Inferred only
EGFR interacts with PDK3ProteinHetionet hetionet:interacts:1956-5165Inferred only
MRPL58 interacts with PDK3ProteinHetionet hetionet:interacts:3396-5165Inferred only
PDHA1 interacts with PDK3ProteinHetionet hetionet:interacts:5160-5165Inferred only
PDK3 interacts with UBCProteinHetionet hetionet:interacts:5165-7316Inferred only
PDK3 interacts with UBDProteinHetionet hetionet:interacts:10537-5165Inferred only
PDK3 participates in Aerobic respiration and respiratory electron transportPathwayReactome R-HSA-1428517Inferred only
PDK3 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
PDK3 participates in Pyruvate metabolismPathwayReactome R-HSA-70268Inferred only
PDK3 participates in Regulation of pyruvate dehydrogenase (PDH) complexPathwayReactome R-HSA-204174Inferred only

Show the remaining 14

PDK3 participates in Regulation of pyruvate metabolismPathwayReactome R-HSA-9861718Inferred only
PDK3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PDK3 participates in Signaling by Nuclear ReceptorsPathwayReactome R-HSA-9006931Inferred only
PDK3 participates in Signaling by Retinoic AcidPathwayReactome R-HSA-5362517Inferred only
PDK3 regulates regulation of glucose metabolic processBiological processgene ontology Q15120|GO:0010906Inferred only
PDK3 regulates regulation of pyruvate decarboxylation to acetyl-CoABiological processgene ontology Q15120|GO:0010510Inferred only
PDK3 regulates regulation of reactive oxygen species metabolic processBiological processgene ontology Q15120|GO:2000377Inferred only
PDK3 decreases the expression of ABCB6ProteinHetionet hetionet:regulates:5165-10058Inferred only
DNAJB1 increases the expression of PDK3ProteinHetionet hetionet:regulates:3337-5165Inferred only
PDK3 decreases the expression of DNM1LProteinHetionet hetionet:regulates:5165-10059Inferred only
PDK3 decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:5165-6192Inferred only
SC5D increases the expression of PDK3ProteinHetionet hetionet:regulates:6309-5165Inferred only
STAT6 increases the expression of PDK3ProteinHetionet hetionet:regulates:6778-5165Inferred only
TNFRSF14 increases the expression of PDK3ProteinHetionet hetionet:regulates:8764-5165Inferred only

Reactions

2 reactions

MAM00219c+ATPMAM00220c+ADP+proton
Catalysed by PDK4 or PDK2 or PDK3 or PDK1
Reaction pageLeft to rightBalance undeterminableEC 2.7.11.2cytosol
Human-GEM MAR09517CC BY 4.0Reference data
L-seryl-[pyruvate dehydrogenase E1 alpha subunit]+ATP(4-)O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]+ADP(3-)+

Other names

3 names

Resolves to: PDK3

Also called: acetyl-transferringPDHK3Pyruvate dehydrogenase kinase isoform 3

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