Proteins/UNIPROT:Q9Y2Z4

YARS2

ProteinUNIPROT:Q9Y2Z4Tyrosine--tRNA ligase, mitochondrial1 compound

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)..

Function from UniProtKB (Q9Y2Z4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · substrate of

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

L-tyrosineCompoundCHEBI:58315Inferred only5 paths5 endpoints

What the reference databases state

GenCC submitters' classifications

3 rows

mitochondrial disease has a germline basis in YARS2DiseaseGenCC HGNC:24249|MONDO:0044970Inferred only
myopathy, lactic acidosis, and sideroblastic anemia has a germline basis in YARS2DiseaseGenCC HGNC:24249|MONDO:0000863Inferred only
myopathy, lactic acidosis, and sideroblastic anemia 2 has a germline basis in YARS2DiseaseGenCC HGNC:24249|MONDO:0013307Inferred only

Statements

21 statements

21 statements · 4 reference databases · Subject: YARS2 · Sources: Bgee, Hetionet, Reactome, Rhea

Order

PHLDA1 covaries with YARS2ProteinHetionet hetionet:covaries:22822-51067Inferred only
TCTN1 covaries with YARS2ProteinHetionet hetionet:covaries:51067-79600Inferred only
YARS2 is expressed in oocyteCell typeBgee ENSG00000139131Inferred only
YARS2 is expressed in secondary oocyteCell typeBgee ENSG00000139131Inferred only
YARS2 interacts with CAND1ProteinHetionet hetionet:interacts:51067-55832Inferred only
CUL3 interacts with YARS2ProteinHetionet hetionet:interacts:51067-8452Inferred only
MRPL58 interacts with YARS2ProteinHetionet hetionet:interacts:3396-51067Inferred only
UBC interacts with YARS2ProteinHetionet hetionet:interacts:51067-7316Inferred only
YARS2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
YARS2 participates in Mitochondrial tRNA aminoacylationPathwayReactome R-HSA-379726Inferred only
YARS2 participates in TranslationPathwayReactome R-HSA-72766Inferred only
YARS2 participates in tRNA AminoacylationPathwayReactome R-HSA-379724Inferred only

Show the remaining 9

CCNB2 decreases the expression of YARS2ProteinHetionet hetionet:regulates:9133-51067Inferred only
DAXX decreases the expression of YARS2ProteinHetionet hetionet:regulates:1616-51067Inferred only
DGKH decreases the expression of YARS2ProteinHetionet hetionet:regulates:160851-51067Inferred only
DNM1L decreases the expression of YARS2ProteinHetionet hetionet:regulates:10059-51067Inferred only
GUK1 decreases the expression of YARS2ProteinHetionet hetionet:regulates:2987-51067Inferred only
PAX8 decreases the expression of YARS2ProteinHetionet hetionet:regulates:7849-51067Inferred only
STAT5A decreases the expression of YARS2ProteinHetionet hetionet:regulates:6776-51067Inferred only
ZNF133 decreases the expression of YARS2ProteinHetionet hetionet:regulates:7692-51067Inferred only
L-tyrosine is a substrate of YARS2CompoundRhea RHEA:10220Inferred only

Reactions

1 reaction

CHEBI:78442+L-tyrosine+ATP(4-)CHEBI:78536+AMP+diphosphate(3-)+hydron
Catalysed by YARS1 or YARS2
Reaction pageLeft to rightBalanced
Rhea RHEA:10220CC BY 4.0Reference data

Other names

2 names

Resolves to: YARS2

Also called: Tyrosyl-tRNA synthetaseTyrRS

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