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Proteins/UNIPROT:Q9Y606
Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA..
Function from UniProtKB (Q9Y606), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
15 statements
15 statements · 2 reference databases · Subject: PUS1 · Sources: Hetionet, WikiPathways
4 reactions
MAM03085cMAM03087c
Catalysed by PUS1
Reaction pageReversibleBalance undeterminableEC 5.4.99.12cytosol
Human-GEM MAR09524CC BY 4.0Reference data
CHEBI:65315CHEBI:65314
Reaction pageLeft to rightBalanced
Rhea RHEA:22376CC BY 4.0Reference data
a uridine in tRNAa pseudouridine in tRNA
4 names
Resolves to: PUS1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54572CC BY 4.0Reference data
a uridine in mRNAa pseudouridine in mRNA
Catalysed by TRUB2 or RPUSD3 or RPUSD2 or TRUB1 or RPUSD4 or PUS7 or PUS7L or PUS1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:56644CC BY 4.0Reference data