Proteins/UNIPROT:Q9NYY8

FASTKD2

ProteinUNIPROT:Q9NYY8

Plays an important role in assembly of the mitochondrial large ribosomal subunit. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. May play a role in mitochondrial apoptosis..

Function from UniProtKB (Q9NYY8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

combined oxidative phosphorylation deficiency 44 has a germline basis in FASTKD2DiseaseGenCC HGNC:29160|MONDO:0030020Inferred only
FASTKD2-related infantile mitochondrial encephalomyopathy has a germline basis in FASTKD2DiseaseGenCC HGNC:29160|MONDO:0015632Inferred only
mitochondrial disease has a germline basis in FASTKD2DiseaseGenCC HGNC:29160|MONDO:0044970Inferred only

Statements

28 statements

28 statements · 3 reference databases · Subject: FASTKD2 · Sources: gene ontology, Hetionet, Reactome

Order

CENPE covaries with FASTKD2ProteinHetionet hetionet:covaries:1062-22868Inferred only
FASTKD2 covaries with FASTKD1ProteinHetionet hetionet:covaries:22868-79675Inferred only
FASTKD2 covaries with PDE3BProteinHetionet hetionet:covaries:22868-5140Inferred only
FASTKD2 interacts with IRF2BP2ProteinHetionet hetionet:interacts:22868-359948Inferred only
MRPL58 interacts with FASTKD2ProteinHetionet hetionet:interacts:22868-3396Inferred only
TRAF6 interacts with FASTKD2ProteinHetionet hetionet:interacts:22868-7189Inferred only
UBC interacts with FASTKD2ProteinHetionet hetionet:interacts:22868-7316Inferred only
FASTKD2 participates in FASTK family proteins regulate processing and stability of mitochondrial RNAsPathwayReactome R-HSA-9837092Inferred only
FASTKD2 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
FASTKD2 participates in Mitochondrial mRNA modificationPathwayReactome R-HSA-9937008Inferred only
FASTKD2 participates in Mitochondrial RNA degradationPathwayReactome R-HSA-9836573Inferred only
FASTKD2 participates in rRNA modification in the mitochondrionPathwayReactome R-HSA-6793080Inferred only

Show the remaining 16

FASTKD2 participates in rRNA processingPathwayReactome R-HSA-72312Inferred only
FASTKD2 participates in rRNA processing in the mitochondrionPathwayReactome R-HSA-8868766Inferred only
FASTKD2 regulates regulation of mitochondrial mRNA stabilityBiological processgene ontology Q9NYY8|GO:0044528Inferred only
FASTKD2 decreases the expression of ARID4BProteinHetionet hetionet:regulates:22868-51742Inferred only
DHRS4 decreases the expression of FASTKD2ProteinHetionet hetionet:regulates:10901-22868Inferred only
DLD decreases the expression of FASTKD2ProteinHetionet hetionet:regulates:1738-22868Inferred only
FASTKD2 decreases the expression of EPN2ProteinHetionet hetionet:regulates:22868-22905Inferred only
FASTKD2 increases the expression of FSD1ProteinHetionet hetionet:regulates:22868-79187Inferred only
FASTKD2 decreases the expression of GNASProteinHetionet hetionet:regulates:22868-2778Inferred only
FASTKD2 increases the expression of IGF2BP2ProteinHetionet hetionet:regulates:22868-10644Inferred only
FASTKD2 increases the expression of LCN2ProteinHetionet hetionet:regulates:22868-3934Inferred only
RET increases the expression of FASTKD2ProteinHetionet hetionet:regulates:5979-22868Inferred only
FASTKD2 decreases the expression of SUZ12ProteinHetionet hetionet:regulates:22868-23512Inferred only
FASTKD2 increases the expression of TATDN2ProteinHetionet hetionet:regulates:22868-9797Inferred only
FASTKD2 decreases the expression of TM9SF3ProteinHetionet hetionet:regulates:22868-56889Inferred only
TWF2 increases the expression of FASTKD2ProteinHetionet hetionet:regulates:11344-22868Inferred only

Other names

2 names

Resolves to: FASTKD2

Also called: FAST kinase domain-containing protein 2, mitochondrialKIAA0971

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