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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q86Y79

PTRH1

Protein·UNIPROT:Q86Y79

Open in the graph

Peptidyl-tRNA hydrolase that cleaves nascent chains-tRNAs that are not stably fixed in the P-site of 60S ribosome-nascent chain complexes. Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes. Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation..

Function from UniProtKB (Q86Y79), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

3 statements

3 statements · 2 reference databases · Subject: PTRH1 · Sources: Hetionet, WikiPathways

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PRNP interacts with PTRH1ProteinHetionet hetionet:interacts:138428-5621Inferred only
PTRH1 participates in miR targeted genes in leukocytesPathwayWikiPathways WP2003Inferred only
PTRH1 participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only

Reactions

2 reactions

water+MAM02626cMAM02625c+MAM03083c
Catalysed by PTRH2 or MRPL58 or PTRH1
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.29cytosol
Human-GEM MAR09522CC BY 4.0Reference data
an N-acyl-L-alpha-aminoacyl-tRNA+wateran N-acyl-L-amino acid+a tRNA+hydron
Catalysed by MRPL58 or PTRHD1

Other names

2 names

Resolves to: PTRH1

Also called: C9orf115PTH

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or

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:54448CC BY 4.0Reference data