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Proteins/UNIPROT:P40337
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR..
Function from UniProtKB (P40337), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
6 rows
331 statements
331 statements · 4 reference databases · Subject: VHL · Sources: gene ontology, Hetionet, Reactome, WikiPathways · Rows fetched: 300
2 names
Resolves to: VHL