Proteins/UNIPROT:Q8IVS2

MCAT

ProteinUNIPROT:Q8IVS2Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria. Also acts as a mitochondrial small ribosomal subunit (mt-SSU) assembly factor..

Function from UniProtKB (Q8IVS2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

optic atrophy 15 has a germline basis in MCATDiseaseGenCC HGNC:29622|MONDO:0957935Inferred only

Statements

11 statements

11 statements · 4 reference databases · Subject: MCAT · Sources: Hetionet, Human-GEM, Reactome, WikiPathways

Order

MRPL58 interacts with MCATProteinHetionet hetionet:interacts:27349-3396Inferred only
UBC interacts with MCATProteinHetionet hetionet:interacts:27349-7316Inferred only
MCAT participates in Fatty acid metabolismPathwayReactome R-HSA-8978868Inferred only
MCAT participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
MCAT participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
MCAT participates in Mitochondrial Fatty Acid Beta-OxidationPathwayReactome R-HSA-77289Inferred only
MCAT participates in Mitochondrial fatty acid synthesis pathwayPathwayWikiPathways WP4317Inferred only
CCDC86 decreases the expression of MCATProteinHetionet hetionet:regulates:79080-27349Inferred only
GUK1 decreases the expression of MCATProteinHetionet hetionet:regulates:2987-27349Inferred only
PKIG increases the expression of MCATProteinHetionet hetionet:regulates:11142-27349Inferred only
CHEBI:1146900 is a substrate of MCATCompoundHuman-GEM MAR01517Inferred only

Reactions

3 reactions

MAM00184m+malonyl-CoACHEBI:1146900+MAM02442m
Catalysed by MCAT
Reaction pageReversibleBalance undeterminableEC 2.3.1.39mitochondrial matrix
Human-GEM MAR01517CC BY 4.0Reference data
MAM00184c+malonyl-CoACHEBI:1146900+MAM02442c
Catalysed by MCAT or FASN
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.85, 2.3.1.39cytosol
Human-GEM MAR02151

Other names

5 names

Resolves to: MCAT

Also called: [Acyl-carrier-protein] malonyltransferaseMCTMitochondrial malonyl CoA:ACP acyltransferaseMitochondrial malonyltransferaseMT

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