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Proteins/UNIPROT:P40126

DCT

Protein·UNIPROT:P40126

Open in the graph

Plays a role in melanin biosynthesis. Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA)..

Function from UniProtKB (P40126), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

oculocutaneous albinism type 8 has a germline basis in DCTDiseaseGenCC HGNC:2709|MONDO:0030899Inferred only

Statements

12 statements

12 statements · 5 reference databases · Subject: DCT · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways

Search this listOrder

NAPSA covaries with DCTProteinHetionet hetionet:covaries:1638-9476Inferred only
DCT participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
DCT participates in GPR143 in melanocytes and retinal pigment epithelium cellsPathwayWikiPathways WP4941Inferred only
DCT participates in Melanin biosynthesisPathwayReactome R-HSA-5662702Inferred only
DCT participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
DCT participates in Metabolism of amino acids and derivativesPathwayReactome R-HSA-71291Inferred only
DCT participates in MITF-M-dependent gene expressionPathwayReactome R-HSA-9856651Inferred only
DCT participates in MITF-M-regulated melanocyte developmentPathwayReactome R-HSA-9730414Inferred only
DCT participates in Neural crest differentiationPathwayWikiPathways WP2064Inferred only
DCT participates in Regulation of MITF-M-dependent genes involved in pigmentationPathwayReactome R-HSA-9824585Inferred only
DCT regulates positive regulation of neuroblast proliferationBiological processgene ontology P40126|GO:0002052Inferred only
DCT requires the cofactor Zn(2+)CompoundUniProt P40126Inferred only

Reactions

2 reactions

MAM02355cMAM01053c
Catalysed by DCT
Reaction pageLeft to rightBalancedEC 5.3.3.12cytosol
Human-GEM MAR06888CC BY 4.0Reference data
CHEBI:57509CHEBI:16875
Catalysed by MIF or DCT
Reaction pageDirection not assertedBalanced
Rhea RHEA:13041CC BY 4.0Reference data

Other names

6 names

Resolves to: DCT

Also called: DTL-dopachrome Delta-isomeraseTRP-2TRP2Tyrosinase-related protein 2TYRP2

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