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Proteins/UNIPROT:Q9H6W3
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (By similarity). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis. Participates in MYC-induced transcriptional activation..
Function from UniProtKB (Q9H6W3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
45 statements
45 statements · 4 reference databases · Subject: RIOX1 · Sources: gene ontology, Hetionet, Reactome, UniProt
3 reactions
N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3]+22-oxoglutarate(2-)+2dioxygenL-lysyl(36)-[histone H3]+2formaldehyde+2succinate(2-)+2carbon dioxide
Catalysed by KDM2B or RIOX1 or KDM2A
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:42032CC BY 4.0Reference data
L-histidyl-[protein]+2-oxoglutarate(2-)+
11 names
Resolves to: RIOX1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54256CC BY 4.0Reference data
N(6)-methyl-L-lysyl-[protein]+2-oxoglutarate(2-)+dioxygenL-lysyl-[protein]+formaldehyde+succinate(2-)+carbon dioxide
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60924CC BY 4.0Reference data